Publications by authors named "P Mattioli"
Objective: The aim of this study was to describe the clinical features of contactin-associated protein-like 2 (CASPR2)-IgG-associated seizures.
Methods: Nine patients were retrospectively collected from two epilepsy centers. For each patient we obtained a full clinical, neurophysiological, and MRI study along with detection of antineuronal autoantibodies from serum and CSF.
Background: Magnetic resonance imaging (MRI) has recently enabled to identify four distinct Alzheimer's disease (AD) subtypes: hippocampal sparing (HpSp), typical AD (tAD), limbic predominant (Lp), and minimal atrophy (MinAtr). To date, however, the natural history of these subtypes, especially regarding the presence of subjects switching to other MRI patterns and their clinical and biological differences, remains poorly understood.
Objective: To investigate the clinical and biological underpinnings of longitudinal atrophy pattern progression in AD.
Article Synopsis
- REM Sleep Behavior Disorder (RBD) is linked to an increased risk of developing neurodegenerative diseases like Parkinson's and dementia, prompting a study of autonomic dysfunction in RBD patients.* -
- The study used advanced methods to analyze sleep patterns and heart rate variability, revealing that RBD patients generally experience lower heart rate variability and are more likely to transition to lighter sleep stages.* -
- Although RBD patients suffer from fragmented sleep and autonomic issues, those with Parkinson's displayed better sleep continuity, potentially due to relief from their PD symptoms during sleep.*
The phenoconversion trajectory from idiopathic/isolated Rapid eye movement (REM) sleep behavior disorder (iRBD) towards either Parkinson's Disease (PD) or Dementia with Lewy Bodies (DLB) is currently uncertain. We investigated the capability of baseline brain [F]FDG-PET in differentiating between iRBD patients eventually phenoconverting to PD or DLB, by deriving the denovoPDRBD-related pattern (denovoPDRBD-RP) from 32 de novo PD patients; and the denovoDLBRBD-RP from 30 de novo DLB patients, both with evidence of RBD at diagnosis. To explore [F]FDG-PET phenoconversion trajectories prediction power, we applied these two patterns on a group of 115 iRBD patients followed longitudinally.
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- - The transition from pediatric to adult care for epilepsy is complex and involves multiple stakeholders, essential for providing high-quality care and preventing negative outcomes in young patients.
- - The study aimed to address the challenges and needs in this transition process from the perspective of adult neurologists through a survey assessing their views on the issue.
- - Results indicate that adult neurologists find the transition challenging and recommend a collaborative approach between child and adult neurologists, along with better training in childhood epilepsy.