Drug Development.

Background: OLX-07010 is an oral small molecule inhibitor of tau self-association that prevented the accumulation of tau aggregates in the htau mouse model expressing wild type human CNS tau isoforms and in P301L tau JNPL3 mice using chronic treatment by administration in diet (Davidowitz et al., 2020, PMID: 31771053; 2023 PMID:37556474). A therapeutic study of JNPL3 mice with chronic treatment from 7-12 months of age inhibited the progression of tau aggregation and improved motor coordination.

Geohazard Identification in Underground Mines: A Mobile App.

Mining is a critical industry that provides essential minerals and resources for modern society. Despite its benefits, the industry is also recognized as one of the most dangerous occupations, with geotechnical hazards being a primary concern. This study introduces the hazard recognition in underground mines application (HUMApp), a mobile application developed to enhance safety within underground mines by efficiently identifying geotechnical hazards, specifically focusing on roof falls.

Wild-Mouse-Derived Gut Microbiome Transplantation in Laboratory Mice Partly Alleviates House-Dust-Mite-Induced Allergic Airway Inflammation.

Laboratory mice are instrumental for preclinical research but there are serious concerns that the use of a clean standardized environment for specific-pathogen-free (SPF) mice results in poor bench-to-bedside translation due to their immature immune system. The aim of the present study was to test the importance of the gut microbiota in wild vs. SPF mice for evaluating host immune responses in a house-dust-mite-induced allergic airway inflammation model without the influence of pathogens.

Riboflavin- and Dextran-Producing FS54 B2: Characterization and Testing for Development of Fermented Plant-Based Beverages.

The use of lactic acid bacteria for developing functional foods is increasing for their ability to synthesize beneficial metabolites such as vitamin B (riboflavin, RF) and postbiotic compounds. Here, the spontaneous mutant FS54 B2 was isolated by treatment of the dextran-producing FS54 strain with roseoflavin. FS54 B2 overproduced RF (4.

sp. nov., sp. nov. and sp. nov. isolated from batfish () in Tahiti Island, French Polynesia.

Ten novel Gram-negative, aerobic, non-sporulating, yellow-pigmented rod-shaped bacterial strains motile by gliding were isolated from marine organisms/environments in French Polynesia. Three of them designated as 190524A05c, 190524A02b and 190130A14a were retrieved from orbicular batfish () mucus. Online database comparisons using 16S rRNA amplicons resulted in over 95% similarity to the genus .