Publications by authors named "P Marzano"

Background: Autologous stem cell transplantation is a treatment modality for several diseases. Prediction of successful mobilization may be useful to optimize hematopoietic stem cell collection.

Study Design And Methods: This was a retrospective study with data from transplantation candidates between September 2015 and December 2021 being analyzed.

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γδ T cells provide rapid cellular immunity against pathogens. Here, we conducted matched single-cell RNA-sequencing and γδ-TCR-sequencing to delineate the molecular changes in γδ T cells during a longitudinal study following mRNA SARS-CoV-2 vaccination. While the first dose of vaccine primes Vδ2 T cells, it is the second administration that significantly boosts their immune response.

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Article Synopsis
  • Higher frequencies of mucosal-associated invariant T (MAIT) cells are linked to a better immune response to the mRNA SARS-CoV-2 vaccine, with the hypothesis that TNF produced by these cells aids B cell activation after immunization.
  • A study analyzed peripheral blood mononuclear cells (PBMCs) from vaccinated adults at various time intervals following the Pfizer-BioNTech vaccine to explore the effects of repeated vaccinations on MAIT cells.
  • Results show that MAIT cells produce TNF in response to the vaccine, which boosts their proliferation and enhances anti-SARS-CoV-2 antibody production, especially activating memory B cells essential for long-term immunity.
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Background: More than 50% of all patients with colorectal cancer (CRC) develop liver metastases (CLM), a clinical condition characterized by poor prognosis and lack of reliable prognostic markers. Vδ1 cells are a subset of tissue-resident gamma delta (γδ) T lymphocytes endowed with a broad array of antitumor functions and showing a natural high tropism for the liver. However, little is known about their impact in the clinical outcomes of CLM.

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Human Vδ2 cells are innate-like γδ T effectors performing potent immune surveillance against tumors. The constitutive expression of NKG2A identifies a subset of Vδ2 T cells licensed with an intrinsic hyper-responsiveness against cancer. Indeed, the transcriptomic profiles of NKG2A and NKG2A cells characterize two distinct "intralineages" of Vδ2 T lymphocytes that appear early during development, keep their phenotypes, and show self-renewal capabilities in adult life.

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