Publications by authors named "P Martineau"
Unlocking the potential of broadly reactive coronavirus monoclonal antibodies (mAbs) and their derivatives offers a transformative therapeutic avenue against severe COVID-19, especially crucial for safeguarding high-risk populations. Novel mAb-based immunotherapies may help address the reduced efficacy of current vaccines and neutralizing mAbs caused by the emergence of variants of concern (VOCs). Using phage display technology, we discovered a pan-SARS-CoV-2 mAb (C10) that targets a conserved region within the receptor-binding domain (RBD) of the virus.
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- A new type of scan called PSMA PET/CT helps doctors see if prostate cancer has come back in men after surgery, but it's not clear what it means when the scan shows no signs of cancer.
- The study looked at 101 older men who had this scan and found that many either didn't get more treatment or received radiation therapy to help fight the cancer.
- After a few years, most men were still doing well, with a 95% chance of not seeing the cancer progress in the first year, and that number dropped a bit over the next two years.
Vascular injuries are serious complications of multiligament knee injuries and can result in catastrophic outcomes. These injuries can range from intimal flaps with no compromise of the distal perfusion to a complete occlusion or transection requiring emergent vascular intervention. Several diagnostic tests, including the measurement of the ankle-brachial index (ABI), conventional angiography, and computed tomography angiography (CTA), are commonly used as diagnostic tools to identify vascular injuries in the context of a multiligament knee injury.
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- The study investigates how left ventricular size affects the accuracy and predictive power of myocardial perfusion imaging (MPI), particularly focusing on smaller hearts.
- It analyzes data from 2,503 patients, assessing outcomes such as major adverse cardiac events (MACE) over an average of 6.4 years, revealing significant risk stratification using stress total perfusion deficit (TPD).
- The findings indicate that stress TPD is a reliable predictor of MACE in both men and women, independent of left ventricular size, suggesting that smaller hearts may not necessarily diminish MPI's prognostic capabilities.
Myocardial inflammation plays a central role in the pathophysiology of various cardiac diseases. While FDG-PET is currently the primary method for molecular imaging of myocardial inflammation, its effectiveness is hindered by physiological myocardial uptake as well as its propensity for uptake by multiple disease-specific mechanisms. Novel radiotracers targeting diverse inflammatory immune cells and molecular pathways may provide unique insight through the visualization of underlying mechanisms central to the pathogenesis of inflammatory cardiac diseases, offering opportunities for increased understanding of immunocardiology.
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