Opportunistic infections and organ-specific diseases in HIV-1-infected children: a cohort study (1990-2006).

Objectives: Highly active antiretroviral therapy (HAART) has dramatically changed the natural history of HIV infection in children, but there are few studies in the literature about the incidence of clinical manifestations after HAART in this population, compared with adults. The aim of this study was to describe the influence of the widespread use of HAART on the development of opportunistic infections and organ-specific diseases in HIV-infected children.

Methods: An observational study of a cohort of 366 vertically HIV-infected children followed from 1990 to 2006 was carried out.

[HIV-1 genetic variability in non Spaniard infected children].

Introduction: The prevalence of HIV-1 non-B subtypes (HIV-NBS) is increasing in Europe, because of emigration from countries where genetic variants are endemic. Although HIV-NBS could have a different clinical evolution and could respond differently to antiretrovirals (AR) than B-subtypes, these variant's response remain undocumented.

Aims: To identify HIV-1 genetic variants and to determine clinical evolution in a non-Spaniard children infected with HIV-1.

Internationally adopted children: what vaccines should they receive?

It is of paramount importance to know the vaccination status in internationally adopted children, so that they can be correctly immunized. This study ascertains the seroprotection rate for vaccine-preventable diseases and the validity of the immunization cards in 637 adopted children. The absence of the immunization card (13% of children) correlated with a poor global vaccine protection.