Pulmonary Artery Vasa Vasorum Damage in Severe COVID-19-Induced Pulmonary Fibrosis.

Background: COVID-19 patients exhibit higher incidence of thrombosis in arteries and veins, including those in lungs. Vasa vasorum, which support large blood vessels, have shown involvement in these pathologic processes.

Methods: To further explore the extent of microvascular damage caused by COVID-19 infection, we examined resected main, right, or left pulmonary artery specimens from patients undergoing bilateral lung transplantation for COVID-19- or non-COVID-19-induced pulmonary fibrosis compared with organ donors by histologic and immunohistologic analyses.

Preliminary study of gunshot residues in entry holes at different angles: Feasibility of using LIBS to support trajectory estimation.

Firearm-related scenarios can be highly complex, involving multiple shooters, firearms, types of ammunition, victims, and various impact zones. Obtaining the maximum amount of information to connect each piece of the puzzle is crucial for resolving these cases. Currently, new tools are being developed in the forensic field that facilitate both fieldwork and laboratory analysis, enabling the estimation of trajectories, identification of shooters, and more.

Single-Cell Lineage Tracing and Clonal State-Fate Analysis.

Lineage tracing has significantly advanced our comprehension in many areas of biology, such as development or immunity, by precisely measuring cellular processes like migration, division, or differentiation across labeled cells and their progeny. Traditional recombinase-based prospective lineage tracing is limited by the need for a priori cell type information and is constrained in the numbers of clones it can simultaneously track. In this sense, clonal lineage tracing with integrated random barcodes offers a robust alternative, enabling researchers to label and track a vast array of cells and their progeny over time.

Validation of an Oral Health Tool for Clinicians to Screen Patients With Cardiovascular Disease.

Aims: To develop and validate a screening tool to identify patients with cardiovascular disease at risk of poor oral health and requiring referrals.

Design: This study was part of a larger pilot study involving a cross-sectional survey and an oral health assessment conducted with patients with cardiovascular disease.

Methods: A four-item screening tool was developed by an expert panel and validated through a cross-sectional survey of patients with cardiovascular disease.