aqueous extract inhibits chronic demyelination and seizures in mice.

Demyelinating diseases are commonly associated with epileptic seizures and have limited management options. Hence, the need to investigate potential options for management of such seizures. extract (AE) was investigated for effect in chronic demyelinating seizures.

Synergistic antidepressant-like effect of xylopic acid co-administered with selected antidepressants.

Background: Xylopic acid (XA), a kaurene diterpene from the dried fruits of has anxiolytic- and antidepressant-like activity in mice and zebrafish. We aimed to assess the potential synergistic antidepressant-like effects of XA when combined with selected antidepressants in the mouse forced-swim test.

Materials And Methods: The antidepressant-like effect of xylopic acid (XA) (10, 30, 100 mgkg), fluoxetine (Flx) (3, 10, 30 mgkg), sertraline (Sert) (3, 10, 30 mgkg), imipramine (Imi) (10, 30, 100 mgkg-1) and ketamine (Ket) (0.

Gut-Brain-axis: effect of basil oil on the gut microbiota and its contribution to the anticonvulsant properties.

Background: Epilepsy is a chronic neurological condition that disrupts the normal functioning of the brain and it is characterized by seizures. Research suggests the involvement of the Gut-Brain axis in epilepsy. This study seeks to determine the role of the gut microbiota in the anticonvulsant effect of basil oil (BO) using antibiotic-depleted and altered germ-free mice against naïve mice in Pentylenetetrazole (PTZ) induced seizure model.