Transcriptomic analysis reveals suppression of steroidogenic acute regulatory protein in gender-specific differences in Alzheimer's disease.

Alzheimer's disease (AD)-related dementia preferentially impacts two-thirds of women and one-third of men. The steroidogenic acute regulatory (StAR) protein mediates the biosynthesis of neurosteroids that sustain diverse neuronal activities. Aging, involving neurosteroidal imbalance, is the predominant risk factor for AD causing dementia.

Glucose-Responsive Insulin Delivery via Surface-Functionalized Titanium Dioxide Nanoparticles: A Promising Theragnostic against Diabetes Mellitus.

Glucose-dependent insulin delivery systems have been recognized as a promising approach for controlling blood sugar levels in individuals with diabetes mellitus (DM). Recently, titanium dioxide nanoparticles have garnered huge attention in scientific research for their small size and effective drug delivery capabilities. In this study, we developed alizarin (AL)-capped phenylboronic acid (PBA)-functionalized titanium dioxide nanoparticles (TiO) for glucose-sensitive insulin delivery (TiO-PBA-INS-AL) aiming to manage both blood sugar levels and its associated organ pathology in DM.

Including sea-level rise and vertical land movements in probabilistic tsunami hazard assessment for the Mediterranean Sea.

Probabilistic tsunami hazard analysis (PTHA) introduces potential biases in tsunami risk assessment if it assumes static coastlines. Global warming, in addition to geological and local factors, may affect sea-level rise in the next few decades. Here, we provide a method that integrates the expected sea-level rise into existing PTHA, updating regional models without further tsunami simulations.

pH-Independent Selective Formation of VO Motif Incorporating a Family of Hydrazone Ligands: Synthesis, Structure, and Luminescence-Based Sensing Studies toward Selective Metal Ions.

Two new dioxidovanadium(V) compounds with the general formula [VO(L)] (L = hydrazone ligand) were synthesized using three different methods (acidic, neutral, and basic media) with either VOSO. 5HO, [VO(acac)], or NHVO as the starting material and hydrazone ligands. In both cases, five coordinated V ions adopted distorted square pyramidal geometry through the coordination of two oxido ligands and one hydrazone ligand.