Publications by authors named "P Mandl"
Objective: To test the reliability of the Outcome Measures in Rheumatology Giant cell arteritis (GCA) Ultrasonography Score (OGUS) and other composite scores in a patient-based exercise involving experts and non-experts in vascular ultrasonography.
Methods: Six GCA patients were scanned twice (two rounds separated ≥3 hours) by 12 experts and 12 non-experts. Non-experts received 90 min of theoretical and 240 min of practical training between rounds 1 and 2.
Article Synopsis
- The study aimed to assess how often tenosynovitis and tendon damage occur in patients with hand osteoarthritis (HOA) and how they affect pain and hand function using both clinical exams and ultrasound (US).
- A total of 86 HOA patients and 23 matched control subjects were evaluated, revealing that 69.8% of HOA patients had tendon involvement compared to only 8.7% of controls, with different rates of damage in flexor and extensor tendons.
- Despite finding significant tendon involvement through US, the results showed no correlation between tendon issues and hand function or reported pain levels in HOA patients.
Article Synopsis
- Women with systemic lupus erythematosus (SLE) face significantly higher rates of maternal and fetal complications compared to those in the standard-risk (SR) population, but the complication rates are similar to those in high-risk (HR) pregnancies.
- In a study comparing 100 women with SLE to HR and SR cohorts, the incidence of maternal complications was 28% for SLE vs. 6.28% for SR, with no significant difference compared to the HR group (29.6%).
- Fetal complications were also higher in the SLE group (55%) compared to the SR group (25.54%), but SLE pregnancies showed a lower incidence of such complications compared to HR pregnancies (75%
Purpose: To evaluate the characteristics, efficacy, and retention of tofacitinib monotherapy in patients with rheumatoid arthritis using data from randomized controlled trials (RCTs) and real-world data (RWD).
Patients And Methods: Three patient groups receiving tofacitinib 5 mg twice daily (BID) monotherapy were defined for post hoc RCT/long-term extension (LTE) analyses: (1) disease-modifying antirheumatic drug (DMARD)-inadequate responder patients from phase 3/3b/4 RCTs; (2) methotrexate-naïve patients from a phase 3 RCT; and (3) index study patients continuing in an LTE study. Outcomes included low disease activity (LDA)/remission rates defined by Clinical Disease Activity Index (CDAI); Disease Activity Score in 28 joints (DAS28-4), erythrocyte sedimentation rate; DAS28-4, C-reactive protein (DAS28-4[CRP]); and rates of/time to discontinuation due to lack of efficacy/adverse events.
Article Synopsis
- Systemic autoimmune rheumatic diseases (SARDs) present challenges during pregnancy, requiring careful planning for optimal disease control and to minimize risks for both the mother and the baby.
- Interdisciplinary care throughout the pregnancy journey, including pre-conception and breastfeeding, is essential for improving outcomes for both mother and child.
- The review outlines important aspects such as pre-pregnancy counseling, medication management during pregnancy, monitoring disease activity, and emphasizes the need for shared decision-making between healthcare providers and patients.