Publications by authors named "P Malkomes"
Transglutaminase 2 promotes epithelial-to-mesenchymal transition by regulating the expression of matrix metalloproteinase 7 in colorectal cancer cells via the MEK/ERK signaling pathway.
Biochim Biophys Acta Mol Basis Dis
January 2025
Article Synopsis
- Tissue transglutaminase 2 (TGM2) and matrix metalloproteinase 7 (MMP7) play critical roles in colon cancer development, influencing epithelial-mesenchymal transition (EMT), which is crucial for cancer cell invasion and migration.
- This study shows that overexpressing TGM2 enhances MMP7 activity, promoting invasive behaviors of colon cancer cells, while knocking down TGM2 has the opposite effect.
- The research suggests that targeting TGM2 may provide a new therapeutic approach to hinder the progression of colon cancer by affecting the MEK/ERK signaling pathway and EMT processes.
Purpose: This study aimed to evaluate the morbidity associated with excisional biopsy in patients with spontaneous gastric perforation.
Methods: A retrospective, single-center, observational study was performed. All consecutive patients with spontaneous gastric perforation who underwent surgical therapy were included.
Background: Prehabilitation is of becoming of growing interest in the medical specialist societies, especially before major surgical procedures in older and frail patients. The body of evidence in steadily growing.
Objectives: Are there good digital solutions for a remote prehabilitation program at home?
Methods: Narrative review of the evidence and current study activities in analogous and digital prehabilitation.
Background: Despite the prognostic relevance of cachexia in pancreatic cancer, individual body composition has not been routinely integrated into treatment planning. In this multicenter study, we investigated the prognostic value of sarcopenia and myosteatosis automatically extracted from routine computed tomography (CT) scans of patients with advanced pancreatic ductal adenocarcinoma (PDAC).
Patients And Methods: We retrospectively analyzed clinical imaging data of 601 patients from three German cancer centers.
Molecular markers for predicting prognosis of colorectal cancer (CRC) patients are urgently needed for effective disease management. We reported previously that the multifunctional enzyme Transglutaminase 2 (TGM2) is essential for CRC cell survival by inactivation of the tumor suppressor p53. Based on these data, we determined the clinical relevance of TGM2 expression and explored its potential as prognostic marker and therapeutic target in CRC.
View Article and Find Full Text PDF