Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD.

Background: Regulation of messenger RNA (mRNA) transport and translation in neurons is essential for dendritic plasticity and learning/memory development. The trafficking of mRNAs along the hippocampal neuron dendrites remains translationally silent until they are selectively transported into the spines upon glutamate-induced receptor activation. However, the molecular mechanism(s) behind the spine entry of dendritic mRNAs under metabotropic glutamate receptor (mGluR)-mediated neuroactivation and long-term depression (LTD) as well as the fate of these mRNAs inside the spines are still elusive.

Clearing the path: Unraveling bisphenol a removal and degradation mechanisms for a cleaner future.

Bisphenol A (BPA) is a prevalent chemical found in a range of consumer goods, which has raised worries about its possible health hazards. Comprehending the breakdown pathways of BPA is essential for evaluating its environmental consequences and addressing associated concerns. This review emphasizes the significance of studying the degradation/removal of BPA, with a specific focus on both natural and artificial routes.

The commitment of the human cell atlas to humanity.

The Human Cell Atlas (HCA) is a global partnership "to create comprehensive reference maps of all human cells-the fundamental units of life - as a basis for both understanding human health and diagnosing, monitoring, and treating disease." ( https://www.humancellatlas.