Targeting the menopause transition with metformin improves breast cancer outcomes, but discontinuation has deleterious effects on metabolic health: Findings from a preclinical model of postmenopausal breast cancer.

Background: Women with obesity and/or type-II-diabetes have an increased breast cancer risk, increased metastasis, and poorer prognosis, especially after menopause. In a rat model of high-fat-diet and menopause-induced weight gain, we previously reported that treatment with the anti-diabetic drug metformin for 8-weeks after ovariectomy (OVX; modeling menopause) reduced growth of existing mammary tumors and inhibited new tumor formation. This identified the menopause transition as a potential window-of-opportunity for interventions to decrease obesity-associated breast cancer incidence and disease progression.

Complete genome sequence of ES191 generated by PacBio sequencing.

We present the complete genome of ES191, isolated from New Zealand in 2011 and known for its strong biofilm ability. The genome consists of a 4,309,604-base pair (bp) circular chromosome (56.9% GC) and a 165,613-bp circular plasmid (55.

Impact of different stall layouts with robotic milking systems on the behavioral pattern of multiparous cows.

The present study aimed to compare the efficiency of different pens and animal flow configuration layouts in freestall pens using a robotic milking system (RMS) with guided flow based on the behavioral patterns of multiparous lactating Holstein dairy cows in a commercial farm. The behavior of 24 cows in freestall pens was evaluated, divided into 4 different stall configurations: original (OR), conversion (CVS), toll-booth I (TBI), and toll-booth II (TBII), each featuring distinct circulation layouts with different configurations of location, position, and number of guided-flow RMS equipment, feed bunk, water trough, commitment pen, sand beds, sorting gates, and one-way gate. Six multiparous cows, parity 2 or 3, with an average (± SD) of 180 ± 20 DIM, were randomly selected from each freestall pen for focal assessment of behavioral patterns.

Genome sequences of three plastic-debris-inhabiting fungi isolated from New Zealand waste and recycling management plants.

and are cosmopolitan fungi of the class Dothideomycetes with few cultured and genomic representatives. Here, we report draft reference genome sequences of sp. F181 (GenBank accession number JAJSLS01), sp.

Evaluation of Extraction Techniques for Recovery of Microalgal Lipids under Different Growth Conditions.

Microalgal lipids contain a wide array of liposoluble bioactive compounds, but lipid extraction remains a critical limitation for their commercial use. An accelerated solvent extraction (ASE) was used to extract lipids from , (), and grown under either standard or nitrogen depletion conditions. Under standard growth conditions, ASE using methanol:chloroform (2:1), methyl -butyl ether (MTBE):methanol:water, and ethanol at 100 °C resulted in the highest recovery of total lipids (352 ± 30, 410 ± 32, and 127 ± 15 mg/g biomass from , , and , respectively).