Publications by authors named "P Macedo"
Sporotrichosis during pregnancy: A retrospective study of 58 cases in a reference center from 1998 to 2023.
PLoS Negl Trop Dis
December 2024
Background: Pregnant women constitute a vulnerable population occasionally affected by zoonotic sporotrichosis. Treatment is challenging due to potentially teratogenic oral medications (itraconazole and saturated potassium iodide solution) or lack of clinical experience during pregnancy (terbinafine). Literature is scarce on sporotrichosis and pregnancy, mainly consisting of case reports.
View Article and Find Full Text PDFExploring validated strategies for screening for eating disorders in adolescents and adults in primary health care: a scoping review protocol.
Syst Rev
November 2024
Background: This study will be the first scoping review dedicated to investigating screening strategies for eating disorders specifically performed in the primary health care setting, as no comprehensive examination has been performed to date. Our primary aim is to explore the available literature and assess and identify validated screening strategies for eating disorders in adolescents and adults within the primary care context.
Methods: The study protocol was developed following the guidance outlined by the Preferred Reporting Items for Systematic reviews and Meta-Analyses Protocols and the Joanna Briggs Institute methodology for scoping reviews.
Article Synopsis
- Zoonotic sporotrichosis, primarily transmitted by cats, has become highly prevalent in Rio de Janeiro, with a study focusing on 43 non-zoonotic cases revealing important epidemiological and clinical data.
- The majority of patients were male and common sources of infection included injuries from plants and soil contact, with a specific fungal species being predominantly responsible for the infections.
- Antifungal susceptibility tests showed some strains resistant to treatment, highlighting the need for ongoing monitoring of antifungal resistance and further investigation into the environmental factors contributing to sporotrichosis.
as a model organism for screening acetylcholinesterase reactivators.
J Toxicol Environ Health A
December 2024
Article Synopsis
- The insecticide chlorpyrifos (CP) inhibits acetylcholinesterase (AChE), leading to neurological issues and affecting organ functions across the body.
- This study assessed various oxime compounds as potential reactivators of AChE to combat CP’s harmful effects, using a new model organism to address ethical concerns in drug screening.
- Results showed that oximes, particularly pralidoxime and K048, effectively reactivated AChE, improved locomotor function, and reduced mortality in CP-exposed organisms, suggesting promising new therapeutic options for AChE-related disorders.
Article Synopsis
- Sporotrichosis diagnosis requires various tests like culture and serum antibody detection, but these methods can sometimes lead to incorrect results.
- This study focused on different patient groups to determine how well specific antibody tests work, using an ELISA method to check for various antibodies in serum samples.
- Findings indicated that certain patients, especially those with nasal lesions and hypersensitivity, had a higher chance of getting false-negative results in antibody detection, highlighting the diagnostic challenges of sporotrichosis.