Early Signs of Autonomic Nervous System Imbalance in Children with High Cardiometabolic Risk.

Objective: Autonomic nervous system is involved in many disorders, and changes in its modulation are the known risk factors for cardiovascular diseases. Its role in metabolic disarrangements in children at high cardio-metabolic risk is not known. Aim of the study is to analyze the relation between clinical-metabolic parameters and autonomic nervous system in children.

Long QT syndrome in chromosome 7q35q36.3 deletion involving KCNH2 gene: Warning for chlorpheniramine prescription.

Background: The deletion of the distal 7q region is a rare chromosomal syndrome characterized by wide phenotypic manifestations including growth and psychomotor delay, facial dysmorphisms, and genitourinary malformations.

Methods: We describe a 6-year-old child with a 12-Mb deletion of the region 7q35q36.3.

Program for the epidemiological evaluation of stroke in Tandil, Argentina (PREVISTA) study: rationale and design.

The availability of population-based epidemiological data on the incident risk of stroke is very scarce in Argentina and other Latin American countries. In response to the priorities established by the World Health Organization and the United Nations, PREVISTA was envisaged as a population-based program to determine the risk of first-ever and recurrent stroke and transient ischemic attack incidence and mortality in Tandil, Buenos Aires, Argentina. The study will be conducted according to Standardized Tools for Stroke Surveillance (STEPS Stroke) methodology and will enroll all new (incident) and recurrent consecutive cases of stroke and transient ischemic attack in the City of Tandil between May 1st, 2013 and April 30, 2015.

Human vascular endothelial growth factor B: characterization of recombinant isoforms and generation of neutralizing monoclonal antibodies.

1. The vascular endothelial growth factor (VEGF) family is a focus of interest with respect to novel therapies for cardiovascular disease. Members of this family bind differentially to three receptor tyrosine kinases, namely VEGF-R1, -R2 and -R3, and to the semaphorin receptors neuropilin 1 and 2.

[Voluntary or accidental ingestion of foreign bodies: clinical considerations in 142 cases].

The authors report on a series of 142 patients who had swallowed foreign bodies over the period 1981-1999. After outlining the various ways in which the foreign bodies were swallowed and the fact that they were eliminated spontaneously by natural routes in 80-90% of cases, the authors deal at some length with the serious complications that occurred in some of these cases, which, as a result of their characteristics and mode of ingestion, may require emergency surgery for their resolution. In particular, the authors describe 6 cases of foreign bodies that were urgently removed by endoscopy and also describe 3 cases in detail (1 perforation and 2 bowel obstructions) in which a laparotomy was required not only to correct the complication but also to definitively clarify the diagnosis.