Publications by authors named "P MICHON"
Article Synopsis
- Lung adenocarcinoma is a serious cancer that is a major cause of death globally, and this study examines how mitochondrial DNA (mtDNA) copy number impacts tumor growth in mice.
- Increased mtDNA levels were found in lung tumors caused by KRAS expression, leading to larger tumors in mice with higher mtDNA and reduced growth when mtDNA was depleted.
- The findings suggest mtDNA copy number is critical for lung cancer progression and could pave the way for new cancer treatments, while immune responses in the lung remained unaffected by mtDNA levels.
[Orthostatic hypotension: focus on a common pathology sometimes misknowned].
Geriatr Psychol Neuropsychiatr Vieil
December 2022
Orthostatic hypotension is a frequent pathology especially in older adults and inhospital patients. Prevalence is increasing with age, and is about 30 % of patients older than 65 years. Orthostatic hypotension is defined as a fall in blood pressure of at least 20 mmHg systolic or 10 mmHg diastolic when standing or during head-up tilt testing.
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- The study investigates Charcot neuroarthropathy (CN) in patients with diabetes, focusing on whether hyperglycemia decreases when an active phase of CN begins.
- Researchers analyzed Hemoglobin A1c (HbA1c) levels in 103 diabetic patients before and during the active phase of CN, looking at changes over six months prior to diagnosis.
- Results indicated a significant decline in HbA1c levels from six months to three months before diagnosis and from six months to the onset of the active phase, suggesting a relationship between reduced blood sugar levels and the onset of CN.