High energy shock waves in the treatment of delayed and nonunion of fractures.

The treatment of delayed and nonunion of fractures by a single extracorporeal dose of high energy shock waves generated in a water medium and focused on the fracture site is reported. The shock waves break up sclerotic bone by producing microfissures and numerous bony fragments because of the difference in impedance between bone (and calculi) and soft tissues. Osteogenesis is stimulated and contributed to union in 70 out of 82 fractures within a reasonable time.

Effect of methotrexate on the pharmacokinetics and renal excretion of cisplatin.

The kinetics of platinum in plasma and erythrocytes, and its renal excretion, have been examined in five patients with non-small cell carcinoma of the lung, after treatment with cisplatin 50 mg/m2 (Platidiame) and, three weeks later, a combination of 50 mg/m2 cisplatin and 40 mg/m2 methotrexate. The patients were given 0.9% saline 1 l 1 h prior to drug application.

Extracorporeal shock wave lithotripsy of stones in the ureter.

In the present paper we report on one-year experience with the application of extracorporeal shock wave lithotripsy (ESWL) in 157 patients with stones in the ureter 63 of which were in the pyeloureteral segment, 52 in the lumbar part and 42 in the distal third. The indications and contraindications for lithotripsy, the peculiarities in performing the manipulation are determined and the results analysed. They are evaluated as very good because 78.

Epidemiology of nickel allergy.

In 2400 consecutive patients at 8 clinics in 5 countries, nickel hypersensitivity was found in 176 cases (7.3%), 19 male (2.1%) and 157 female (10.