Publications by authors named "P M van Diemen"
The introduction of wire-free microcirculatory resistance index from functional angiography (angio-IMR) promises swift detection of coronary microvascular dysfunction, however it has not been properly validated. We sought to validate angio-IMR against invasive IMR and PET derived microvascular resistance (MVR). Moreover, we studied if angio-IMR could aid in the detection of ischemia with non-obstructive coronary arteries (INOCA).
View Article and Find Full Text PDFMicrovascular resistance reserve in relation to total and vessel-specific atherosclerotic burden.
Eur Heart J Cardiovasc Imaging
November 2024
Aims: The relationship between coronary artery atherosclerosis and microvascular resistance remains unclear. This study aims to clarify the relationship between total atherosclerotic and vessel-specific atherosclerotic burden and microvascular resistance reserve (MRR).
Methods And Results: In this post-hoc analysis of the PACIFIC 1 trial, symptomatic patients without prior coronary artery disease (CAD) underwent [15O]H2O positron emission tomography, coronary computed tomography angiography (CCTA) and invasive fractional flow reserve (FFR).
Article Synopsis
- The study aimed to compare the effectiveness of Coronary Computed Tomography Angiography (CCTA) alone and in combination with Computed Tomography Perfusion (CTP) for detecting in-stent restenosis (ISR).
- After reviewing over 18,000 studies, researchers included 20 relevant studies in their meta-analysis, focusing on those that used advanced 64-slice CT technology.
- Results showed that both CCTA and CCTA + CTP had high diagnostic accuracy for ISR, suggesting these imaging methods should be used regardless of a patient's previous stent placement.
Background: The applicability of quantitative flow ratio (QFR), a nonhyperemic, invasive coronary angiography-derived computation of fractional flow reserve (FFR), has not been studied in coronary artery bypass grafts. We sought to explore the correlation and diagnostic agreement between QFR and FFR in saphenous vein grafts (SVGs).
Methods And Results: A total of 129 prospectively included patients (mean age 73±8 years, 84% male) with prior coronary artery bypass grafting underwent invasive coronary angiography and pressure-derived functional assessment in 150 nonoccluded SVGs.
Article Synopsis
- - The study evaluates the effectiveness of quantitative perfusion cardiac magnetic resonance (QP-CMR) imaging in detecting significant coronary artery disease (CAD) in patients with a history of CAD and new chest pain, comparing it with visual assessment of stress perfusion CMR and quantitative PET imaging.
- - Involving 145 patients with prior heart issues, the research found QP-CMR's sensitivity at 66%, which is lower than PET at 80%, but its specificity is on par with both v-CMR and PET at about 60-63%.
- - Overall, the study concludes that QP-CMR's diagnostic performance is similar to that of both other imaging methods for identifying hemodynamically significant CAD, defined by fractional