Publications by authors named "P M Whitfield"
African trypanosomiasis is a widespread disease of human and veterinary importance caused by various with a globally devastating impact and a need for novel treatment options. We here provide a comprehensive preclinical evaluation of nucleoside analogues, 6-thioether-modified tubercidins, with curative activity against African trypanosomiasis. Promising hits were identified following screening against the most relevant trypanosome species.
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- A chronic subdural haematoma (cSDH) is an increasingly common condition in older adults, characterized by a collection of fluid and blood in the subdural space, with no existing guidelines for optimal care from symptom onset to recovery.
- This paper outlines the creation of consensus-based recommendations for the management of cSDH, developed by a multidisciplinary committee that included healthcare professionals, patients, and caregivers.
- The final guideline features 67 recommendations spread across eight themes, addressing key aspects such as diagnosis, surgical procedures, non-operative management, and post-operative care despite a general lack of high-quality evidence in the literature.
There are several antimicrobial options for treating urinary tract infections in children. Although cefdinir is commonly used, better options exist. We developed an intervention bundle to reduce the use of cefdinir in favor of cephalexin.
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- * Inositol phosphorylceramide (IPC) plays a key role in leishmania species, with IPC synthase (IPCS) being a critical enzyme; clemastine fumarate has emerged as a potential IPCS inhibitor and an anti-leishmanial agent.
- * Research reveals that while clemastine fumarate inhibits IPCS and alters metabolic pathways, its main action may involve different targets, suggesting further investigation is needed for effective treatment strategies.
Risk factors for treatment of asymptomatic bacteriuria in a rural health system.
Am J Health Syst Pharm
November 2024
Purpose: Asymptomatic bacteriuria is often inappropriately treated, leading to antimicrobial-related adverse events and contributing to antimicrobial resistance. This study examined the asymptomatic bacteriuria treatment rate at a rural Wisconsin health system and the patient-specific factors that may be influencing clinicians' decisions to treat.
Methods: This is a retrospective descriptive report of patients admitted from January to May 2022 at 7 rural Wisconsin hospitals.