Publications by authors named "P M Wagoner"
Intermediate wheatgrass (IWG, [Host] Barkworth & D. R. Dewey) has been developed as a perennial grain crop to provide ecosystem services, environmental benefits, and human food.
View Article and Find Full Text PDFMany biomedical engineering degree programs lack substantial immersive clinical experiences for undergraduate students, creating a need for clinical immersion programs that contribute to training objectives that emphasize current clinical needs (Becker in Eur J Eng Educ 31:261-272, 2006; Davis et al. in J Eng Educ 91:211-221, 2002; Dym et al. in J Eng Educ 94:103-120, 2005).
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- Voltage-gated sodium channels (Nav) are crucial for the electrical activity in excitable cells, and the study highlights two specific small molecule inhibitors that target these channels with high selectivity for human Nav1.3/Nav1.1 and Nav1.7.* -
- The inhibitors identified interact with a unique region of the Nav channel structure, specifically the S1-S4 voltage sensor segment of Domain 4, which is different from where other known inhibitors bind.* -
- The research suggests that certain amino acid residues in the Nav channels determine selectivity for the inhibitors and differences in how various species respond to them, providing insights into developing new targeted treatments.*
KCNQ2 (Kv7.2) and KCNQ3 (Kv7.3) are voltage-gated K(+) channel subunits that underlie the neuronal M current.
View Article and Find Full Text PDFActivation of tetrodotoxin-resistant sodium channels contributes to action potential electrogenesis in neurons. Antisense oligonucleotide studies directed against Na(v)1.8 have shown that this channel contributes to experimental inflammatory and neuropathic pain.
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