Publications by authors named "P M Vannini"
Importance: Depressive symptoms in older adults may be a harbinger of Alzheimer disease (AD), even in preclinical stages. It is unclear whether worsening depressive symptoms are manifestations of regional distributions of core AD pathology (amyloid) and whether cognitive changes affect this relationship.
Objective: To evaluate whether increasing depressive symptoms are associated with amyloid accumulation in brain regions important for emotional regulation and whether those associations vary by cognitive performance.
Background: Declining ability to independently perform instrumental activities of daily living (IADL) is a hallmark of early-stage Alzheimer's disease (AD). Financial capacity, an aspect of IADL, includes financial skills such as balancing a checkbook and making change and is potentially sensitive to early decline in cognitive abilities, raising the question of how financial capacity is affected by buildup of cerebral tau and amyloid-hallmarks of AD pathology.
Objectives: This study aimed to examine the relationship between cerebral tau, amyloid, and their interaction with change in financial capacity over time.
Article Synopsis
- The study examines how changes in everyday functioning, particularly through a phone task, relate to tau and amyloid levels in cognitively healthy older adults.
- Seventy-six participants were assessed over approximately two years, using tasks that simulated real-life activities like refilling prescriptions and selecting doctors.
- The results found that higher levels of baseline amyloid and tau were linked to a faster decline in performance on one specific task (APT-PCP), suggesting early indicators of cognitive decline can be detected through these assessments.
Article Synopsis
- The study explores how olfactory pathways are linked to memory-related areas of the brain, suggesting a potential role in the progression of Alzheimer's disease (AD).
- Researchers analyzed olfactory identification along with neuroimaging techniques and genetic data from 89 cognitively normal older adults to understand how AD-related tau pathology spreads.
- Results show that deficits in odor identification are tied to tau buildup in the olfactory system, indicating that tau progresses from the medial temporal lobe to the olfactory regions rather than the other way around, with certain genetic factors possibly increasing susceptibility to this process.
Answering Huijbens and Jóhannesson's call to investigate tourist destination development through a relational ontology marked by a vital materialism, this paper focuses on the creation of the Muraka. The Muraka is the underwater villa of the Conrad Maldives Rangali Island-an ultra-luxury resort located in Alifu Dhaalu Atoll. No social scientific research has ever been conducted at underwater hotels.
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