Publications by authors named "P M Van Hagen"
Introduction: Severe COVID-19 is associated with reduced absolute lymphocyte counts, suggesting that lymphocyte subsets may serve as predictors of clinical outcomes in affected patients. Early identification of patients at risk for severe disease is crucial for optimizing care, accurately informing patients and their families, guiding therapeutic interventions, and improving patient flow in the ED. Given that immunosuppressive drugs significantly impact lymphocyte profiles, we aimed to determine the association between prior use of immunosuppressive drugs, lymphocyte subsets, and COVID-19 severity in our population with a high prevalence of immunosuppression.
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- The shortage of General Practitioners (GPs) in Europe, especially in rural Germany, is exacerbated by an aging workforce and a trend of new doctors opting out of primary care or working part-time.
- Understanding the factors influencing medical students' specialty choices is vital, including their personality traits, which can impact their interest in General Practice.
- The study conducted at the University of Würzburg surveyed medical students to analyze the relationships between personality traits from the Five-Factor Model and their intention to pursue careers in General Practice, using statistical methods like linear regression.
Objective: To optimise the organisation of care and encourage the adoption of good clinical practices, the RarERN Path methodology was designed within ERN ReCONNET. The aim of our work was to report the application of RarERN Path on systemic sclerosis within the ERN ReCONNET centres, providing a feasible and flexible organisational reference model for optimising the systemic sclerosis care pathway in different countries.
Methods: RarERN Path is a six-phase methodology which enables the creation of a reference organisational model co-designed on the basis of the expertise of different stakeholders.
Clinical performance of a novel and rapid bioassay for detection of thyroid-stimulating immunoglobulins in Graves' orbitopathy patients: a comparison with two commonly used immunoassays.
Front Endocrinol (Lausanne)
October 2024
Background: For the selective detection of thyroid-stimulating hormone receptor antibodies with stimulating properties (thyroid-stimulating immunoglobulins; TSI), a novel and rapid bioassay (Turbo TSI) has been introduced. We evaluate the clinical performance of Turbo TSI in Graves' orbitopathy (GO) patients and compare it to a bridge-based TSI binding immunoassay and third generation TSH-R-binding inhibitory immunoglobulins (TBII) assay. Also, we investigate the association of Turbo TSI and TBII measurements with GO activity and severity, as well as response to intravenous methylprednisolone (IVMP), and compare results to previous findings on the bridge-based TSI binding immunoassay.
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- This study investigated serum levels and activity of interferon (IFN) in patients with sarcoidosis and tuberculosis (TB), focusing on those with uveitis, to understand IFN's role in these diseases.
- Serum samples from patients in Indonesia (TB) and the Netherlands (sarcoidosis) were analyzed using specific assays to measure IFN types and activity, as well as the presence of autoantibodies against IFN.
- The results showed significantly higher levels of IFNα2 and IFNγ in sarcoidosis patients compared to TB patients, particularly in those with uveitis, suggesting that IFN may be a useful marker for distinguishing between these two similar conditions.