Publications by authors named "P M Schweizer"
Article Synopsis
- The study examines the outcomes of cryoballoon-ablation for atrial fibrillation in women, focusing on those with heart failure with preserved ejection fraction (HFpEF) compared to those without.
- Women with HFpEF displayed worse health indicators, including higher left atrial volume, increased left ventricular mass, reduced walking distances, and higher left atrial pressures.
- Results showed that women with HFpEF had more frequent hospitalizations due to AF and did not experience significant improvements in heart failure symptoms or quality of life after the procedure, suggesting they represent a high-risk group.
Background: Pulsed field ablation (PFA) is a safe and effective technology for catheter ablation of atrial fibrillation (AF). Multiple PFA-platforms for AF ablation have been developed. However, evidence comparing the real-world implementation and performance of different PFA systems is still limited.
View Article and Find Full Text PDFDiffusion is one of the most fundamental concepts in materials science, playing a pivotal role in materials synthesis, forming, and degradation. Of particular importance is solid state interdiffusion of metals which defines the usable parameter space for material combinations in the form of alloys. This parameter space can be explored on the macroscopic scale by using diffusion couples.
View Article and Find Full Text PDFArticle Synopsis
- Cardiac macrophages play a crucial role in enhancing electrical conduction through the atrioventricular node (AV) in mice and may influence the effectiveness of antiarrhythmic drugs like flecainide.
- In experiments, mice with modified macrophages showed no significant issues in electrical conduction but had a reduced response to flecainide, reflected in less pronounced changes in heart rhythm intervals.
- Coupling between macrophages and cardiomyocytes improves the drug's effects by increasing the presence of specific proteins (Cx43 and Na1.5) on the cell membrane, leading to greater changes in cell membrane potential and action potential duration.