Publications by authors named "P M Rist"
Background And Objectives: Migraine is strongly comorbid with irritable bowel syndrome (IBS), one of several gastrointestinal (GI) conditions that are distinguished by symptomatic profiles that are partly overlapping. Potential shared mechanisms of migraine and the GI conditions were investigated by assessing shared genetics on a genome-wide basis.
Methods: Analyses leveraged genome-wide summary statistics from large-scale genetic studies for migraine, including by aura status, IBS, peptic ulcer disease (PUD), gastrointestinal reflux (GERD), functional dyspepsia (FD), diverticular disease (DD), and the immune-related inflammatory bowel disease (IBD) or its constituents, ulcerative colitis (UC) and Crohn disease (CD).
Background: Observational studies have reported inconsistent relationships between migraine and the risk of intracranial aneurysm and subarachnoid hemorrhage (SAH).
Objective: To determine whether genetic liability to migraine is associated with risk of intracranial aneurysm and aneurysmal SAH.
Methods: This study was designed as a two-sample Mendelian randomization (MR) analysis.
Article Synopsis
- Researchers explored how adding sulfur to propargylic carboxylates affects gold-catalyzed reactions involving alkynes.
- These reactions lead to the creation of functionalized indole products under mild conditions using a regiodivergent approach.
- Selective carboxylate migrations (both 1,2 and 1,3) were achieved, with indole attaching in a 1,4 position relative to the sulfenyl group, influenced by factors like the catalyst system and counterion.
Chronic nonspecific neck pain (CNNP) is prevalent among health care workers, with particularly high rates among nurses. Nurses experiencing CNNP often report decreased job satisfaction, increased absenteeism, and reduced productivity. In recent years, nonpharmacologic approaches have gained attention as effective treatments for the management of CNNP, with exercise and manual therapies representing two of the most common.
View Article and Find Full Text PDFBackground And Objectives: Migraine and Parkinson disease (PD) are common neurologic disorders, which are hypothesized to share some pathophysiologic mechanisms. However, data on the association between migraine and risk of developing PD are sparse. We estimate the effect of migraine, migraine subtypes, and migraine episode frequency on the risk of developing PD in middle-aged and older women.
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