Publications by authors named "P M Pierorazio"
Purpose: To evaluate long-term outcomes of primary chemoablation using a mitomycin reverse thermal gel (UGN-101) in patients with low-grade upper tract urothelial carcinoma.
Materials And Methods: Patients who participated in the OLYMPUS trial (TC-UT-03, NCT02793128) and achieved a complete response (CR) after 6-weekly doses of UGN-101 were followed up to 12 months after initial CR. Those with CR at study completion were eligible for long-term follow-up for up to 5 years or until disease recurrence, progression, or death.
Article Synopsis
- Single-port (SP) robotic surgery is being compared to multi-port (MP) surgery to assess their effectiveness in robotic radical nephrectomy (RN), focusing on various outcomes like surgery time and recovery.* -
- In a study of 341 patients, the SP group (14% of the total) had smaller tumors and longer operative times compared to the MP group but similar overall safety and recovery metrics.* -
- SP robotic surgery may lead to shorter hospital stays and smaller incisions, despite longer surgery times, illustrating its potential benefits while maintaining safety comparable to MP methods.*
Article Synopsis
- - Testicular germ cell tumors (TGCTs) are rare but their incidence is rising globally, with varying rates across different regions and ethnicities. This review examines the changing patterns and identifies risk factors associated with TGCT.
- - The research included a systematic review of 53 reports, revealing that genetic predisposition accounts for about 44% of TGCT heritability, as well as various risk factors like in utero chemical exposure and behavioral issues such as marijuana use.
- - Conclusions suggest that the increase in TGCT cases may be linked to socioeconomic changes and migration, necessitating further research and better screening programs to address the rising incidence.
Modern advances in systemic and localized therapies for patients with renal cell carcinoma (RCC) have significantly improved patients' outcomes. If disease progression occurs after initial treatment, clinicians often have multiple options for a first salvage therapy. Because salvage and initial treatments both may affect overall survival time, and they may interact in unanticipated ways, there is a growing need to determine sequences of initial therapy and first salvage therapy that maximize overall survival while maintaining quality of life.
View Article and Find Full Text PDFUrologists suffer from one of the highest rates of burnout, with negative effects for both physicians and patients. We share simple mindfulness-based strategies as invaluable tools for improving mental health, regulating physical and emotional responses to stressors, and strengthening resilience.
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