[Radioimmunologic research in the complex assessment of thyroid status in primary hypothyroidism].

Radioimmunoassay data on the determination of the plasma levels of free and bound forms of thyroid hormones and TSH in various types of primary hypothyrosis were analyzed. The variability of analyzed indices was revealed; changes in the thyroid status according to the results of hormonal investigations were more noticeable in idiopathic hypothyrosis, the least noticeable in patients with hypothyrosis operated on for diffuse toxic goiter. Changes detected in patients with severe-type hypothyrosis did not depend on the type of disease.

[Characteristics of the clinical picture, hormonal status and humoral immunity in older patients with diffuse toxic goiter].

Radioimmunoassays, immunological and radioreceptor methods were used for a study of the levels of T3, T4, TSH, thyroglobulin, antibodies to thyroglobulin and microsomal antigen, immunoglobulins suppressing thyrotropin binding in 92 patients with diffuse toxic goiter aged over 50. There was discrepancy between the prevalence of severe types of disease in this group of patients and an insignificant rise of T3 and T4 levels. Changes in the immune status pointed to an increase in immunodeficiency which became progressive with aging of the organism, and increasing sensitivity to damaging agents.

[Status of the hypothalamo-hypophyseal system in patients with diffuse toxic goiter].

Disorder of function of the hypothalamus-thyroid system in patients with diffuse toxic goiter is accompanied by change of the hormonal activity of the hypothalamohypophyseal-adrenocortical and hypothalamohypophyseal-ovarian systems. It is particularly marked in persons with heredity aggravated by thyroid diseases or/and diabetes mellitus.

[Reaction of the thyroid gland to a single and prolonged administration of prolactin].

A study was made of the thyroid and hypophysis response to the administration of a summary analogous dose of prolactin injected in a single dose or in the course of 5 days. Experiments were made on female rats at the diestrus stage. The content of thyroid hormones and thyrotropic hormone (TTH) in the blood was determined by radioimmunoassay.