[Prophylaxis and treatment of hemorrhagic complications of operative interventions in patients with hemophilia A and Villebrand's disease].

Hemophilia A and Villebrand's disease owe similar clinical features, for their treatment the preparations, containing factor VIII and Villebrand's factor are used. Preoperatively it is necessary, first of all, to establish the disease diagnosis and its form definitely and then an optimal scheme of hemostatic therapy must be selected with its intraoperative and postoperative correction under control of laboratory monitoring. It is important to reveal timely a hemostasis disorders and a hemophilia of inhibitory form occurrence.

[Prophylaxis and treatment of complications after splenectomy performed for various diseases and trauma of the organ].

Analytic digest of the literature data and observations of their own were adduced, concerning the results of splenectomy (CE), performed for various indications. SE was performed in 2059 patients, including 1656--suffering the blood system diseases. After SE performance the occurrence of speciphic (the splenic fuction loss) and other severe postoperative complications is possible, severity of which depends on the main disease severity and the operation traumaticity.

[Treatment of patients wtih malignant lymphoma with freeze-dried cord blood].

It has been ascertained that in patients with malignant lymphomas, employment of cryopreserved cells of the cord blood (CB) is associated with a high efficiency of therapy of the underlying medical condition. With introduction of CB into the test-system of the donor's blood the T-lymphocytes radiosensitivity has been shown to be increased during the Go- and S-periods of the cell cycle, which fact should be taken account of in planning radiotherapy in oncological patients. A decrease in the level of aneuploid lymphocytes against the background of blast-transformation as a result of transfusion of CB may suggest normalization of the pool of lymphocytes.

[The outlook for the creation of a bank of cryopreserved cord blood for clinical use].

Appraisal of morphological and functional features of cord blood cells involving identification of precursor cells marked with specific monoclonal antibodies makes it possible to regard cord blood as biologically valuable hemopoietic tissue with a high repopulation potential. Studies aimed at developing optimal conditions of cryopreservation allow the stocks of biologically valuable tissue to be built up.