Publications by authors named "P M Pego-Fernandes"
Effects of paclitaxel and methotrexate associated with cholesterol-rich nanoemulsions on ischemia-reperfusion injury after unilateral lung transplantation in rats.
Sci Rep
December 2024
Currently, the barrier to successful lung transplantation is ischemia and reperfusion injury, which can lead to the development of bronchiolitis obliterans. Paclitaxel and methotrexate are drugs known to inhibit cell proliferation and have anti-inflammatory effects, and the association of these drugs with cholesterol-rich nanoparticles has been shown to be beneficial in the treatment of other transplanted organs. Thirty-three male Sprague Dawley rats were divided into 3 groups: Basal group, no intervention; Control group, received only nanoparticles; Drug group, paclitaxel and methotrexate treatment.
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- The study investigates the environmental and financial benefits of telemedicine for patients with tracheal disease in Brazil, highlighting the challenges of traveling to outpatient visits.
- Data was collected from 1,767 telemedicine consultations, revealing substantial savings of over 2.2 million kilometers traveled, resulting in an estimated reduction of 353,000 kg of CO2 emissions and approximately $305,000 in transportation costs.
- The findings emphasize the potential of telemedicine to enhance accessibility while promoting sustainability in healthcare, suggesting that these results could shape future public policies to support telemedicine, particularly in underserved areas.
Introduction: Alpha-1-antitrypsin deficiency (A1AD) is a genetically determined antiproteinase deficiency that predisposes to early-onset emphysema and liver disease. Lung transplantation (LTx) is the final therapeutic option. Behçet's disease (BD) is a rare autoimmune disease characterized by oral and genital ulcers and deep venous thrombosis associated with large-vessel and small-vessel vasculitis and aneurysms.
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