Publications by authors named "P M Newberne"
Article Synopsis
- The study aimed to examine the toxic effects of various types of radiation (γ-ray, proton, and iron ion) on human thyroid cells (HTori-3), focusing on cell transformation and survival.
- The researchers tested L-selenomethionine (SeM) as a protective agent against radiation-induced changes, finding that it enhanced cell survival when administered after exposure.
- The results showed that radiation exposure led to reduced cell survival and the ability of HTori-3 cells to grow independently from a surface was linked to their tumor-forming potential in mice, confirming the cells' tumorigenic nature.
Gamma-cyclodextrin (gamma-CD) is a cyclic alpha-(1,4)-linked oligosaccharide consisting of eight glucose molecules. Like other cyclodextrins, gamma-CD can form inclusion complexes with a variety of organic molecules because the inner side of the torus-like molecule is less polar than the outer side. In foods, gamma-CD may be used as a carrier for flavors, vitamins, polyunsaturated fatty acids, and other ingredients.
View Article and Find Full Text PDFThe present study was undertaken to determine whether the Bowman-Birk inhibitor (BBI) could prevent colon carcinogenesis in rats treated with dimethylhydrazine (DMH) and whether there were adverse side effects associated with treatment with BBI for cancer prevention. BBI was evaluated in the forms of purified BBI (PBBI) or an extract of soybeans enriched in BBI, termed BBI concentrate (BBIC). The results demonstrate that PBBI and BBIC reduced the incidence and frequency of tumors in DMH-treated rats compared with animals treated with DMH alone.
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