Publications by authors named "P M Minoprio"
We detected arenavirus RNA in 1.6% of 1,047 bats in Brazil that were sampled during 2007-2011. We identified Tacaribe virus in 2 Artibeus sp.
View Article and Find Full Text PDFHemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored.
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- COVID-19 has led to over a million deaths globally, with significant gaps in understanding its neurological effects, despite known lung disease mechanisms.
- The study analyzed changes in brain cells (astrocytes) from Syrian hamsters infected with SARS-CoV-2, revealing disruptions in metabolic processes related to carbon metabolism and glycolysis, linked to neurological disorders.
- Findings indicate that SARS-CoV-2 affects brain regions like the hippocampus and cortex, potentially leading to neurological symptoms such as memory loss and cognitive impairment in infected individuals.
As part of efforts to combat the Covid-19 pandemic and decrease the high transmissibility of the new coronavirus, SARS-CoV-2, effective inactivation strategies, such as UV-C decontamination technologies, can be reliably disseminated and well-studied. The present study investigated the susceptibility of a high viral load of SARS-CoV-2 in filtering facepiece respirators (FFR) N95, surgical mask, cotton fabric mask and N95 straps under three different doses of UV-C, applying both real-time PCR (qPCR) and plaque formation assays to quantify viral load reduction and virus infectivity, respectively. The results show that more than 95% of the amount of SARS-CoV-2 RNA could be reduced after 10 min of UV-C exposure (0.
View Article and Find Full Text PDFChagas disease is a life-threatening illness caused by the parasite . The diagnosis of the acute form of the disease is performed by trained microscopists who detect parasites in blood smear samples. Since this method requires a dedicated high-resolution camera system attached to the microscope, the diagnostic method is more expensive and often prohibitive for low-income settings.
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