Publications by authors named "P M Martinez Perez-Crespo"
Differences in clinical outcomes of bloodstream infections caused by Klebsiella aerogenes, Klebsiella pneumoniae and Enterobacter cloacae: a multicentre cohort study.
Ann Clin Microbiol Antimicrob
May 2024
Article Synopsis
- - The study reclassified Klebsiella aerogenes into the Klebsiella genus and aimed to evaluate the clinical outcomes of bloodstream infections (BSI) caused by K. aerogenes compared to K. pneumoniae and Enterobacter cloacae.
- - Researchers analyzed data from hospitalized patients with monomicrobial BSI from October 2016 to March 2017, using various outcomes to compare the infections, including mortality and recurrence rates within 30 days.
- - Findings indicated that K. aerogenes infections had a lower frequency of mortality or recurrence (6.9%) compared to E. cloacae (20.8%) and K. pneumoniae (19.0%), suggesting a potentially better
Whole-genome characterisation of Escherichia coli isolates from patients with bacteraemia presenting with sepsis or septic shock in Spain: a multicentre cross-sectional study.
Lancet Microbe
April 2024
Article Synopsis
- - The study focuses on characterizing *Escherichia coli* (E. coli) blood isolates that cause sepsis or septic shock, as these infections are common and often severe, leading to critical health outcomes in affected patients.
- - Data from a multicenter study in Spain involved whole-genome sequencing of E. coli blood isolates from patients over 14 with diagnosed sepsis or septic shock, identifying various microbiological features, including phylogroups, sequence types, virulence factors, and antimicrobial resistance (AMR) genes.
- - Results showed that most isolates belonged to phylogenetic group 1, with specific sequence types such as ST131 and ST73 being the most common, but there were no significant geographical
Background: The Clinical Trial of Sarilumab in Adults With COVID-19 (SARICOR) showed that patients with coronavirus disease 2019 (COVID-19) pneumonia and increased levels of interleukin (IL)-6 might benefit from blockade of the IL-6 pathway. However, the benefit from this intervention might not be uniform. In this subanalysis, we sought to determine if other immunoactivation markers, besides IL-6, could identify which subgroup of patients benefit most from this intervention.
View Article and Find Full Text PDFConventional Hospitalization versus Sequential Outpatient Parenteral Antibiotic Therapy for Bacteremia: Post-Hoc Analysis of a Multicenter Observational Cohort.
Antibiotics (Basel)
January 2023
It is not known whether sequential outpatient parenteral antimicrobial (OPAT) is as safe and effective as conventional hospitalization in patients with S. aureus bacteremia (SAB). A post-hoc analysis of the comparative effectiveness of conventional hospitalization versus sequential OPAT was performed in two prospective Spanish cohorts of patients with S.
View Article and Find Full Text PDFObjectives: To determine the incidence of cardiac device-related infection (CDRI) among patients with cardiac device (CD) during late-onset bloodstream infection (BSI) and to identify the risk factors associated with CDRI.
Methods: Patients with a CD (cardiac implantable electronic devices -CIED- and/or prosthetic heart valve -PHV-) and late-onset-BSI (>1 year after the CD implantation/last manipulation) were selected from the PROBAC project, a prospective, observational cohort study including adult patients with bacteraemia consecutively admitted to 26 Spanish hospitals from October 2016 to March 2017. Multivariate analyses using logistic regression were performed to identify the risk factors associated with CDRI.