Publications by authors named "P M Markus"

Article Synopsis
  • Fibroblast heterogeneity significantly impacts cancer progression, making it crucial to understand different fibroblast types for developing effective cancer treatments.
  • In pancreatic ductal adenocarcinoma (PDAC), cancer-associated fibroblasts (CAFs) are the predominant cell type, and the study identifies how the MAPK signaling pathway influences their differentiation into specific phenotypes.
  • The study introduces a novel "mapCAF" phenotype associated with certain tumor cells and immune response characteristics, suggesting that targeting these specific CAFs could improve treatment strategies for various cancers.
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One-dimensional dissolution of a layered compound in a nonpolar organic solvent is reported for the first time. A high-aspect ratio fluorohectorite modified with a cationic surfactant (dioctadecyldimethylammonium) showed spontaneous delamination into monolayer nanosheets in chloroform.

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Background: Despite the prognostic relevance of cachexia in pancreatic cancer, individual body composition has not been routinely integrated into treatment planning. In this multicenter study, we investigated the prognostic value of sarcopenia and myosteatosis automatically extracted from routine computed tomography (CT) scans of patients with advanced pancreatic ductal adenocarcinoma (PDAC).

Patients And Methods: We retrospectively analyzed clinical imaging data of 601 patients from three German cancer centers.

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Unlabelled: Basis of acute pharyngitis pathogenesis is an inflammatory process at the entrance gate of the infection. Therefore, local immunity study proves to be the most informative. Difficulty in making that type of assessment is lack of generally accepted reference values and biological sampling techniques.

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Purpose: Patients with BRAF-mutant metastatic colorectal cancer (mCRC) have a dismal prognosis. The best strategies in these patients remain elusive. Against this background, we report the clinical course of patients with BRAF-mutant mCRC to retrieve the best treatment strategy.

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