Publications by authors named "P M Kutty"
Article Synopsis
- - The EPIC study analyzed data from 2,272 adults hospitalized for pneumonia to understand the prevalence of Mycoplasma pneumoniae (Mp) using PCR testing on throat swabs from 2010 to 2012.
- - Only 43 patients (1.8%) tested positive for Mp, primarily affecting younger adults (median age: 45), with some experiencing severe cases leading to ICU admissions, but no in-hospital deaths were reported.
- - Factors linked to higher Mp detection included being younger and having certain radiographic findings, indicating the need for better testing methods to improve diagnosis and treatment options for pneumonia patients.
Nearly a decade after the National Academy of Medicine released the "Improving Diagnosis in Health Care" report, diagnostic errors remain common, often leading to physical, psychological, emotional, and financial harm. Despite a robust body of research on potential solutions and next steps, the translation of these efforts to patient care has been limited. Improvement initiatives are still narrowly focused on selective themes such as diagnostic stewardship, preventing overdiagnosis, and enhancing clinical reasoning without comprehensively addressing vulnerable systems and processes surrounding diagnosis.
View Article and Find Full Text PDFIncubation period of infection in hospitalized patients and long-term care facility residents: a prospective cohort study.
Antimicrob Steward Healthc Epidemiol
September 2024
Background: The incubation period for infection (CDI) is generally considered to be less than 1 week, but some recent studies suggest that prolonged carriage prior to disease onset may be common.
Objective: To estimate the incubation period for patients developing CDI after initial negative cultures.
Methods: In 3 tertiary care medical centers, we conducted a cohort study to identify hospitalized patients and long-term care facility residents with negative initial cultures for followed by a diagnosis of CDI with or without prior detection of carriage.
Article Synopsis
- The study focused on the immune response to SARS-CoV-2 infection and COVID-19 vaccination among 37 nursing home residents, highlighting the importance of this high-risk group.
- Researchers measured antibody levels and memory B cell responses to evaluate the impact of vaccinations and infections over time.
- Results indicated that while vaccination boosts the immune response, there is a decline in antibody levels over time, and individuals who get infected after vaccination show lower antibody levels compared to those who remain uninfected.
Importance: Despite modest reductions in the incidence of hospital-onset Clostridioides difficile infection (HO-CDI), CDI remains a leading cause of health care-associated infection. As no single intervention has proven highly effective on its own, a multifaceted approach to controlling HO-CDI is needed.
Objective: To assess the effectiveness of the Centers for Disease Control and Prevention's Strategies to Prevent Clostridioides difficile Infection in Acute Care Facilities Framework (hereafter, the Framework) in reducing HO-CDI incidence.