Publications by authors named "P M Kuhn"
Background: Physical separation contributes to parental trauma and poor bonding in the context of therapeutic hypothermia (TH) for hypoxic-ischemic encephalopathy (HIE). Parental holding (PH) may improve parents' experience. We aim to determine the physiological and behavioral stability of the newborn held by the parents during TH.
View Article and Find Full Text PDFAim: Healthcare givers are exposed to stress and therefore are at risk of the development of pathologies. We aimed to provide recommendations regarding psychosocial risks such as stress, moral distress, burnout syndrome or secondary stress syndrome in neonatal care units to best support neonatal healthcare givers.
Methods: We searched PubMed for articles published from 1 January 2017 to 1 December 2023 by using the keywords burnout OR (moral and distress) AND neonatal unit.
Article Synopsis
- The research investigates how prostate cancer adapts to changing environments and the role of the Polyaneuploid Cancer Cell (PACC) state in metastasis, suggesting that PACC can enhance metastatic potential.
- Evidence from previous studies shows that the presence of PACC in patient tumors correlates with a higher risk of future metastasis, prompting the use of innovative methods to analyze circulating and disseminated tumor cells from animal models.
- The findings reveal that a significant majority of these tumor cells were in the PACC state, and specific traits associated with PACC contribute to its ability to spread and colonize new sites, raising concerns about the effectiveness of certain cancer treatments that may inadvertently promote metastasis.
Background/objectives: Up to 30% of patients with breast cancers will develop brain or leptomeningeal metastases, and this risk is especially high with HER2-positive cancers. For patients with central nervous system metastases, cerebrospinal fluid (CSF) liquid biopsies are a promising opportunity to monitor disease, inform treatment, and predict prognosis. This pilot study investigated CSF liquid biopsy analytes from three patients diagnosed with central nervous system metastases based on imaging but not confirmed via clinical cytology.
View Article and Find Full Text PDFArticle Synopsis
- Therapeutic resistance in cancer, especially in advanced prostate cancer, contributes to high mortality as patients often relapse after initial treatments.
- Research on circulating tumor cells with increased genomic content (CTC-IGC) from 44 advanced prostate cancer patients reveals a link to poorer survival outcomes and clonal origins, indicating polyploidization.
- Identification of new RNA and protein markers associated with chemotherapy resistance, such as HOMER1, TNFRSF9, and LRP1, suggests pathways for improving cancer treatment and understanding relapse mechanisms.