A fault-tolerant control strategy to estimate and compensate the temperature sensor bias in supermarket refrigeration systems.

The paper proposes a data-driven fault-tolerant control (FTC) strategy to construct and accommodate the bias on ambient temperature measurements in supermarket refrigeration systems. The bias, which is caused by direct or indirect exposure of the sensor to the sun, can have a significant impact on the refrigeration system's energy consumption. Based on analysis of the real data a comprehensive model of the bias is developed and then used to generate realistic scenarios for testing the proposed FTC method.

Candidate CSPG4 mutations and induced pluripotent stem cell modeling implicate oligodendrocyte progenitor cell dysfunction in familial schizophrenia.

Schizophrenia is highly heritable, yet its underlying pathophysiology remains largely unknown. Among the most well-replicated findings in neurobiological studies of schizophrenia are deficits in myelination and white matter integrity; however, direct etiological genetic and cellular evidence has thus far been lacking. Here, we implement a family-based approach for genetic discovery in schizophrenia combined with functional analysis using induced pluripotent stem cells (iPSCs).

[Depression during the perimenopause].

Background: Women are believed to be more vulnerable to depression during the perimenopause than during the premenopausal period. In clinical practice little attention has been given to the relationship between the menopause and depression.

Aim: To provide an overview of the literature on the relationship between the perimenopause and the development of depression and to analyse the relationship between hormonal fluctuations and depression.

Characteristics, prevalence, risk factors, and underlying mechanism of hyponatremia in elderly patients treated with antidepressants: a cross-sectional study.

Objectives: The aims of this study were to describe the characteristics of hyponatremia in elderly users of antidepressants, to determine the prevalence and risk factors for hyponatremia, and to identify the underlying mechanisms.

Study Design: Cross-sectional study (March 2007-April 2009) with prospectively collected data. Patients were older than 60 years, used antidepressants, and had a complete geriatric assessment.

Two-year follow-up of a randomized controlled trial of stepped care cognitive behavioral therapy to prevent recurrence of depression in an older population.

Objective: This study aims to determine the long-term effect of a stepped care cognitive behavioral therapy prevention program for depression in older people and the factors predicting or moderating outcome.

Methods: In a randomized controlled trial, 136 participants, aged 55 years or older, who had been treated for depression, received during 12 months a stepped care program (SCP) or care as usual (CAU) and were then followed up for a second year. Outcome was defined as the start of a new mental health treatment for depression in a specialized outpatient setting, as recorded in the patients' electronic medical records.