Promotion of healthy aging through the nexus of gut microbiota and dietary phytochemicals.

Aging is associated with the decline of tissue and cellular functions, which can promote the development of age-related diseases like cancer, cardiovascular disease, neurodegeneration, and disorders of the musculoskeletal and immune systems. Healthspan is the length of time an individual is in good health and free from chronic diseases and disabilities associated with aging. Two modifiable factors that can influence healthspan, promote healthy aging, and prevent the development of age-related diseases, are the diet and microbiota in the gastrointestinal tract (gut microbiota).

Biallelic variants in cause variable clinical presentations, including sensorineural hearing loss, leukodystrophy, and ovarian insufficiency.

Combined oxidative phosphorylation deficiency (COXPD) is a rare multisystem disorder which is clinically and genetically heterogeneous. Genome sequencing identified biallelic variants in individuals from five unrelated families with presentations ranging from Perrault syndrome (primary ovarian insufficiency and sensorineural hearing loss) to severe childhood onset of leukodystrophy, learning disability, microcephaly and retinal dystrophy. Complexome profiling of fibroblasts from affected individuals revealed reduced levels of the small and, a more pronounced reduction of, the large mitochondrial ribosomal subunits.

Seropositivity to louping ill virus in dogs in the UK.

Background: Louping ill virus (LIV) is a tick-borne flavivirus that can cause fatal meningoencephalomyelitis in dogs. Four dogs with confirmed LIV infection and a case series of dogs with suspected flavivirus infection have been reported in the UK. However, underreporting of LIV infection due to lack of testing is suspected.

Science-Consistent Climate Health Beliefs As Predictors of Climate Behaviors and Support for Provisions and a Carbon Emissions Tax.

Understanding the factors associated with acceptance of climate action is central in designing effective climate change communication strategies. An exploratory factor analysis of 12 science-consistent beliefs about the existence, causes, and consequences of climate change reveals three underlying factors: climate change [a] is real and human caused, [b] has increased the frequency of extreme weather events, and [c] negatively affects public health. In the presence of demographic, ideological, and party controls, this health factor significantly predicts a 3-6 percentage point increase in respondents' [a] willingness to advocate for climate change; [b] reported personal pro-climate behaviors; and [c] support for government policies addressing climate change.