Publications by authors named "P M Holterhus"
Objective: 17β-Hydroxysteroid dehydrogenase 3 deficiency (17β-HSDD) and 5α-reductase type 2 deficiency (5α-RD) are rare 46,XY differences of sex development (DSD). This study aims to enlarge the limited knowledge on long-term gonadal function and gonadal pathology in these conditions.
Design: Retrospective multicentre cohort study.
Introduction: Dehydroepiandrosterone sulphate is increased in formerly small-for-gestational age singletons and in smaller twins compared to their normal-weight co-twin. Less is known concerning other adrenal hormones. We compared diurnal salivary profiles in monozygotic twins with intra-twin birthweight (bw) differences to analyse the long-term impact of bw and persistent intra-twin auxological differences on various adrenal hormones.
View Article and Find Full Text PDFTo locate and fertilize the egg, sperm probe the varying microenvironment prevailing at different stages during their journey across the female genital tract. To this end, they are equipped with a unique repertoire of mostly sperm-specific proteins. In particular, the flagellar Ca channel CatSper has come into focus as a polymodal sensor used by human sperm to register ligands released into the female genital tract.
View Article and Find Full Text PDFArticle Synopsis
- This study investigates how gender-affirming hormonal therapy (GAHT) affects gut microbiota in transgender individuals, focusing on the nuanced impact of sex steroids on microbial changes.
- Thirty-six participants (17 trans women and 19 trans men) were analyzed for shifts in gut microbiota before and after 12 weeks of GAHT, using advanced sequencing techniques.
- Findings revealed significant changes in specific gut bacteria related to affirmed gender, indicating that GAHT leads to distinct microbial profiles and may affect health outcomes for trans men and women.
Introduction: Partial androgen insensitivity syndrome (PAIS) is a rare condition that is reported to be commonly associated with gynecomastia in males.
Objectives: To assess the management of gynecomastia in male PAIS.
Materials And Methods: Retrospective review of males with PAIS over the age of 10 years in the I-DSD registry.