Combining [Lu]Lu-DOTA-TOC PRRT with PARP inhibitors to enhance treatment efficacy in small cell lung cancer.

Purpose: Small cell lung cancer (SCLC) is a highly aggressive tumor with neuroendocrine origin. Although SCLC frequently express somatostatin receptor type 2 (SSTR2), a significant clinical benefit of SSTR2-targeted radionuclide therapies of SCLC was not observed so far. We hypothesize that combination treatment with a PARP inhibitor (PARPi) could lead to radiosensitization and increase the effectiveness of SSTR2-targeted therapy in SCLC.

An assessment of Sri Lankan radiographer's knowledge and awareness of radiation protection and imaging parameters related to patient dose and image quality in computed tomography (CT).

Introduction: As computed tomography (CT) examinations have considerably risen, safe operation is essential to reduce the patients' dose. The main objective of this study was to evaluate the level of knowledge and awareness regarding the CT exposure parameters and radiation protection in CT imaging among Sri Lankan radiographers.

Methods: An online survey-based study was devised and distributed among the Sri Lankan CT radiographers working in 63 CT units.