Structure-Activity Relationship of Ciprofloxacin towards S-Spike Protein of SARS-CoV-2: Synthesis and Evaluation.

The recent outbreak of the coronavirus (COVID-19) pandemic, caused by the SARS-CoV-2 virus, has posed serious threats to global health systems. Although several directions have been put by the WHO for effective treatment, use of antibiotics, particularly ciprofloxacin, in suspected and acquired Covid-19 patients has raised an even more serious concern of antibiotic resistance. Ciprofloxacin has been reported to inhibit entry of SARS-CoV-2 into the host cells via interacting with the spike (S) protein.

Differential modulation of the hepatocellular metabolome, cytoprotective and inflammatory responses due to endotoxemia and lipotoxicity.

The present work aimed to examine the primary mechanisms of liver damage, namely the impact of gut-derived endotoxins along the gut-liver axis and adipose-derived free fatty acids along the adipose-liver axis. These processes are known to play a significant role in the development of hepatic inflammation and steatosis. Although possible overlapping in the pathogenesis was expected, these processes have unique pathophysiological consequences.

Optimizing nutrient management for Kodo millet (Paspalum scrobiculatum L.) in the Alfisols of Southern India through modeling soil, plant, and fertilizer interactions.

Balanced nutrition will be rewarding to profitable and sustainable yield of Kodo millet. In this context, soil test crop response (STCR) experiments on kodo millet were conducted from 2020 to 2022 to assess relationships between yield, soil, plant, and fertilizer nitrogen (N), phosphorus (P), and potassium (K) and calibrate optimum nutrient doses for attaining yield targets. The Basic parameters, i.

Development of high-performance inducible and secretory expression vector and host system for enhanced recombinant protein production.

The production of lipopolysaccharide (LPS)-free recombinant proteins from culture supernatants is of great interest to biomedical research and industry. Due to the LPS-free cell wall structure and the well-defined secretion factor B (SecB)-dependent secretion pathway, Gram-positive bacteria are a superior alternative to Escherichia coli expression systems. However, the lack of inducible expression systems for high yields has been a bottleneck.