Publications by authors named "P M De Siena"

Bicuspid aortic valve disease is the most prevalent congenital heart disease, affecting up to 2% of the general population. The presentation of symptoms may vary based on the patient's anatomy of fusion, with transthoracic echocardiography being the primary diagnostic tool. Bicuspid aortic valves may also appear with concomitant aortopathy, featuring fundamental structural changes which can lead to valve dysfunction and/or aortic dilatation over time.

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Premature ventricular contractions (PVCs) are a common form of arrhythmic events, often representing an idiopathic and benign condition without further therapeutic interventions. However, in certain circumstances PVCs may represent the epiphenomenon of a concealed structural heart disease (SHD). Surface 12‑leads EKG and 24-h dynamic EKG are necessary to assess their main characteristics such as site of origin, frequency and complexity.

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Article Synopsis
  • - The study aimed to explore the impact of TOMM40 genotype (Xg vs. AA carriers) on mortality and cardiovascular issues in patients with advanced atherosclerosis, particularly looking at cardiovascular events and device implantations like pacemakers and defibrillators.
  • - After enrolling 276 patients with serious carotid stenosis or limb ischemia, researchers did not find significant differences in overall mortality between the two genotypes, but Xg carriers had higher rates of fatal cardiovascular events.
  • - Notably, Xg carriers also showed an increased incidence of left bundle branch block (LBBB) compared to AA carriers, while right bundle branch block (RBBB) showed a trend towards higher rates in Xg but without statistical significance
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A data-driven reduced order model (ROM) based on a proper orthogonal decomposition-radial basis function (POD-RBF) approach is adopted in this paper for the analysis of blood flow dynamics in a patient-specific case of atrial fibrillation (AF). The full order model (FOM) is represented by incompressible Navier-Stokes equations, discretized with a finite volume (FV) approach. Both the Newtonian and the Casson's constitutive laws are employed.

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Micra AV represents a leadless endocardial pacing system able to detect atrial contractions providing atrioventricular synchrony. A reduction of myocardial contractility may be detected in case of first-degree atrioventricular block (AVB). In six patients with first-degree AVB (PQ interval ≥220 msec) was evaluated the left ventricle global longitudinal strain (LV GLS) by speckle tracking (ST) echocardiography during single-lead atrial sensing ventricular pacing (VDD) stimulation as compared with spontaneous rhythm (SR), 24-48 h after Micra AV implantation.

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