Publications by authors named "P M Brooks"
In recent years, a small number of people with rare diseases caused by unique genetic variants have been treated with therapies developed specifically for them. This pioneering field of genetic N-of-1 therapies is evolving rapidly, giving hope for the individualized treatment of people living with very rare diseases. In this Review, we outline the concept of N-of-1 individualized therapies, focusing on genetic therapies, and illustrate advances and challenges in the field using cases for which therapies have been successfully developed.
View Article and Find Full Text PDFBackground: Obesity is associated with increased infection risk after primary total joint arthroplasty. In this retrospective cohort analysis, we sought to assess the association between body mass index (BMI) and infection recurrence after two-stage revision total joint arthroplasty for periprosthetic joint infection (PJI).
Methods: Patients were grouped by BMI (< 30, 30 to 40, and ≥ 40) as non-obese, obese, and morbidly obese, and assessed for associations and timing of PJI reinfection as well as readmissions and complications.
Article Synopsis
- The research focuses on the fruit fly Drosophila melanogaster as a crucial model in neuroscience, aided by extensive resources like the FlyWire whole-brain connectome and a hierarchical annotation of neuron classes and types.
- The study reveals 8,453 annotated cell types, with 4,581 being newly identified, highlighting the complexity of the fly brain and emphasizing the difficulty in reidentifying some hemibrain cell types in FlyWire.
- A new definition of cell type is proposed based on cell similarities across different brains, and the study illustrates findings related to neuron connectivity, structural stability, and a consensus atlas for the fly brain's neuroanatomy, supporting future comparative studies.
Australian honey samples from four botanical genera (Lophostemon, Eucalyptus, Macadamia and Corymbia) were investigated for their phenolic content. An improved phenolic extraction and high-performance liquid chromatography-diode array detection (HPLC-DAD) analysis method allowed for the rapid and reliable identification of phenolic compounds. A concentrated liquid-liquid extraction method with an acidified aqueous solution and acetonitrile was optimised to isolate phenolic compounds from the honey matrix.
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