Publications by authors named "P M Athira"
Objectives: This study aimed to compare the effectiveness of three intra-canal sealer activation techniques: ultrasonic, Lentulospiral activation, and GP cone-mediated ultrasonic activation on dentinal tubule penetration of a bioceramic (BIO-C) root canal sealer and AH Plus jet sealer with single cone obturation.
Materials And Methods: Eighty single-rooted straight canal teeth were randomly divided into two main groups - BIO-C sealer and AH Plus jet sealer ( = 40). Each group was further divided into four subgroups, based on the three activation techniques: ultrasonics, Lentulospiral, gutta-percha cone-mediated ultrasonic, and a control.
Hepcidin is a cysteine-rich antimicrobial peptide that plays an important role in fish immunity. In the current study, we report a novel isoform of hepcidin (Jd-Hep) from Sin croaker, Johnius dussumieri, with an open reading frame (ORF) of 258 nucleotide bases that encodes 85 amino acids containing a signal peptide (24 amino acids), a prodomain (35 amino acids) and a biologically active mature peptide (26 amino acids). Phylogenetic tree analysis showed that J.
View Article and Find Full Text PDFAvailability of novel antimicrobial agents is an urgent necessity to combat the growing threat posed by multidrug-resistant bacteria, prompting exploration of marine antimicrobial peptides (AMPs) as potential solutions. Crustacean AMPs are equitably diverse in terms of structure and function, making them consistent templates for novel antimicrobials. From Scylla olivacea gill transcriptome cDNA, a putative Crustin AMP sequence of 333 nucleotides, encoding a 111 amino acid Crustin Type-I isoform was identified.
View Article and Find Full Text PDFArticle Synopsis
- * The 96-hour LC value for cadmium was determined to be 3.03 mg L, with chronic tests revealing effects at concentrations as low as 0.20 mg L, demonstrating severe dosedependent impacts on the mussels’ physiological functions.
- * Key findings included increased levels of antioxidant enzymes indicating oxidative stress, a decrease in energy-related metrics (like respiration and excretion), and a significant reduction in protein, carbohydrate, and lipid levels, all of which suggest serious
Antibacterial Efficacy and Mechanisms of Action of a Novel Beta-Defensin from Snakehead Murrel, Channa striata.
Probiotics Antimicrob Proteins
July 2024
Article Synopsis
- Beta-defensins from fish are important antimicrobial peptides that help fight bacterial infections in aquatic species, and this study focuses on CsDef, a specific peptide from the snakehead murrel.
- CsDef was produced recombinantly, showing strong antibacterial activity against various fish pathogens, with notable efficacy measured by MIC and percentage inhibition rates.
- The peptide operates through multiple mechanisms against bacteria, is safe for human red blood cells and mammalian cells, demonstrates anticancer potential, and shows stability under diverse conditions, suggesting it could be useful in aquaculture applications.