Publications by authors named "P Lynn"

Article Synopsis
  • - The study evaluated the cost-effectiveness of fruquintinib, a treatment for patients with refractory metastatic colorectal cancer, compared to a placebo based on the data from the FRESCO-2 trial.
  • - It found that while fruquintinib provided some survival benefits, with incremental gains of 0.108 life years and 0.073 quality-adjusted life years, the treatment's high cost of US$112,294 resulted in extremely high cost-effectiveness ratios (ICERs).
  • - Ultimately, the study concluded that fruquintinib is not cost-effective in the US context when measured against standard willingness-to-pay thresholds, suggesting implications for its pricing and reimbursement policies. *
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Background: Recent interest in how neural oscillations reflect the flow of information through the brain has led to partitioning electroencephalography (EEG) recordings into periodic (i.e., oscillatory) and aperiodic (i.

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Background: The use of closed-incision negative-pressure wound therapy (iNPWT) has increased in the last decade across surgical fields, including colectomy.

Aim: To compare postoperative outcomes associated with use of iNPWT following open colectomy from a large national database.

Methods: A retrospective review of patients who underwent operations from 2015 to 2020 was performed using the National Surgical Quality Improvement Program (NSQIP) Targeted Colectomy Database.

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Inflammatory bowel disease (IBD) is associated with an increased risk of colorectal cancer. When IBD patients develop a rectal cancer, this should be treated with the same oncological principles and guidelines as the general population. Rectal cancer treatment includes surgery, chemotherapy, and radiation therapy (RT).

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Background: Middle and late adolescence is the period in a person's life that is most vulnerable to mental health problems. To enable an evidence base that can support policies to prevent such problems, it is crucial to have good quality, reliable, and accurate measurement tools for mental well-being. One of them is the Short Warwick-Edinburgh Mental Well-Being Scale (SWEMWBS).

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