Publications by authors named "P Lupo"
Article Synopsis
- A study analyzed childbirth outcomes in male adolescents and young adults (AYAs) with cancer, identifying a sample of nearly 43,000 cases over a 20-year period.
- The research found that 18% of these AYAs had live births within ten years post-diagnosis, with higher rates observed in those with thyroid cancer compared to gastrointestinal cancer.
- Results indicated increased chances of preterm birth and low birth weight among offspring of male AYAs with cancer, emphasizing the need for reproductive counseling for this group.
Background: Methotrexate is an important component of curative therapy in childhood acute lymphoblastic leukemia (ALL), but the role of genetic variation influencing methotrexate clearance and transport in toxicity susceptibility in children with ALL is not well established. Therefore, we evaluated the association between suspected methotrexate pharmacogenomic variants and methotrexate-related neurotoxicity.
Methods: This study included children (aged 2-20 years) diagnosed with ALL (2005-2019) at six treatment centers in the southwest United States.
Purpose Of Review: We provide an overview of the etiology of childhood cancer, the state of the literature, and highlight some opportunities for future research, including technological advancements that could be applied to etiologic studies of childhood cancer to accelerate our understanding.
Recent Findings: Risk factors of childhood cancer were summarized based on demographics and perinatal factors, environmental risk factors, and genetic risk factors. Overall, demographics and perinatal factors are the most well studied in relation to childhood cancer.
Background: Patients with relapsed rhabdomyosarcoma (RMS) are treated with varying approaches and have a poor overall survival (OS). We performed an observational comparison of salvage regimens exploring whether high-dose alkylator combinations were associated with longer OS.
Procedure: We categorized 110 patients with relapsed RMS from five institutions into two groups, those treated with regimens including a high-dose alkylator (Group A) and those treated without a high-dose alkylator (Group B).
Article Synopsis
- - The study investigates laterality defects, focusing on the genetic variations linked to congenital heart disease (CHD) by analyzing sequencing data from three cohorts, uncovering a higher occurrence of digenic variants compared to control groups.
- - A digenic model involving 115 known laterality defect genes revealed significant rates of trans-heterozygous digenic variants in affected individuals, particularly in the Baylor, Kids First, and PCGC cohorts (ranging from 2.8% to 13.5%).
- - The results suggest that epistatic interactions between genes play a crucial role in the genetics of laterality defects, with 23% of identified digenic pairs found in structural complexes of motile