Publications by authors named "P Lunetti"

Wearable technology has advanced significantly, offering real-time monitoring of athletes' physiological parameters and optimizing training and recovery strategies. Recent developments focus on biosensor devices capable of monitoring biochemical parameters in addition to physiological ones. These devices employ noninvasive methods such as sweat analysis, which reveals critical biomarkers like glucose, lactate, electrolytes, pH, and cortisol.

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Background: Oxidative stress, associated with diseases and aging, underscores the therapeutic potential of natural antioxidants. Flavonoids, known for scavenging free radicals and modulating cell signaling, offer significant health benefits and contribute to longevity. To explore their in vivo effects, we investigated the antioxidant activity of quercetin, apigenin, luteolin, naringenin, and genistein, using as a model organism.

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Article Synopsis
  • The study focuses on proteins Ctp1 and Yhm2 in yeast that help transport citrate across the mitochondrial inner membrane, affecting metabolic pathways and respiration.
  • Researchers conducted experiments on yeast mutant cells lacking these proteins to see how it impacted mitochondrial respiration and the organization of respiratory complexes III and IV.
  • Findings revealed that deleting either protein led to impaired respiration, with differences in subunit expression and increased sensitivity to oxidative damage in cells lacking Yhm2, highlighting the connection between citrate transport and respiratory chain activity.
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The antipsychotic drug clozapine demonstrates superior efficacy in treatment-resistant schizophrenia, but its intracellular mode of action is not completely understood. Here, we analysed the effects of clozapine (2.5-20 µM) on metabolic fluxes, cell respiration, and intracellular ATP in human HL60 cells.

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Differently from higher eukaryotic cells, in the yeast there are two mitochondrial carrier proteins involved in the transport of citrate: Ctp1 and Yhm2. Very little is known about the physiological role of these proteins. Wild-type and mutant yeast strains deleted in and were grown in media supplemented with a fermentable (glucose) or a nonfermentable (ethanol) carbon source.

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