Publications by authors named "P Louzada-Junior"
Article Synopsis
- RF titers are significant in the pathophysiology of rheumatoid arthritis (RA) and vary in their clinical impact, with high RF titers linked to poorer health outcomes.
- A study with 1,097 RA adults found a substantial portion had positive RF, with high titers prevalent, and identified associations of high RF with factors such as tobacco use and higher body mass index.
- High RF levels correlated with increased disease activity, reduced functional capacity, and greater use of corticosteroids and biological drugs, indicating a need for careful monitoring in RA patients.
Article Synopsis
- - The study aimed to review the impact of non-surgical periodontal treatment on rheumatoid arthritis symptoms, specifically looking at the 28-joint Disease Activity Score (DAS28) and inflammatory markers like C-reactive protein and erythrocyte sedimentation rate, from existing systematic reviews.
- - Researchers conducted thorough electronic searches for relevant studies up to August 2024, including 10 systematic reviews (six with meta-analyses), which collectively examined data before and after the treatment.
- - Findings indicated that non-surgical periodontal treatment significantly reduced levels of C-reactive protein, erythrocyte sedimentation rate, and DAS28 in individuals with rheumatoid arthritis, with a notable reduction in DAS28 observed after three months. *
Cardiovascular disease (CVD) is the leading cause of death in rheumatoid arthritis (RA). Resistin is an adipokine that induces adipose tissue inflammation and activation of monocytes/macrophages via adenylate cyclase-associated protein-1 (CAP1). Resistin levels are increased in RA and might cause perivascular adipose tissue (PVAT) dysfunction, leading to vascular damage and CVD.
View Article and Find Full Text PDFBackground: Infections increase mortality and morbidity and often limit immunosuppressive treatment in rheumatoid arthritis patients.
Objective: To analyze the occurrence of serious infections and the associated factors in a cohort of rheumatoid arthritis patients under real-life conditions.
Methods: We analyzed data from the REAL, a prospective observational study, that evaluated Brazilian RA patients, with clinical and laboratory data collected over a year.
Bone regeneration is crucial for repairing bone tissue following various injuries. Research techniques that enable the study of metabolic changes in bone tissue under different conditions are important for understanding bone repair and remodeling. This study used bone scintigraphy to evaluate osteogenesis secondary to osteotomy in a preclinical model of New Zealand rabbits.
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