Publications by authors named "P Lonati"

Article Synopsis
  • - The collaboration between the authors and Professor Shoenfeld's group began in the late 80s, focusing on the anti-phospholipid syndrome (APS) and its underlying mechanisms.
  • - Their studies identified β2 glycoprotein I (β2GPI)-dependent antibodies as key factors that disrupt endothelial function, which is crucial to APS's development.
  • - Recent research has expanded to explore parallels between APS and COVID-19, enhancing understanding through animal models and further studies on endothelial behavior in both conditions.
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Article Synopsis
  • The study focused on identifying biomarkers that could help predict the hospitalization risk in patients with mild COVID-19 during the first pandemic wave in Northern Italy.
  • Researchers analyzed blood samples from 76 symptomatic SARS-CoV-2 positive patients and matched healthy controls, measuring levels of various inflammatory markers.
  • Results indicated that elevated levels of calprotectin and neutrophil extracellular traps (NETs) were associated with hospitalized patients, while neopterin levels increased more significantly in hospitalized patients, suggesting these biomarkers could aid in assessing risk levels for COVID-19 patients.
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Two-dimensional in vitro cultures have represented a milestone in biomedical and pharmacological research. However, they cannot replicate the architecture and interactions of in vivo tissues. Moreover, ethical issues regarding the use of animals have triggered strategies alternative to animal models.

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Introduction: Studies exploring alterations in blood coagulation and platelet activation induced by COVID-19 vaccines are not concordant. We aimed to assess the impact of four COVID-19 vaccines on platelet activation, coagulation, and inflammation considering also the immunization dose and the history of SARS-CoV-2 infection.

Methods: TREASURE study enrolled 368 consecutive subjects (161 receiving viral vector vaccines -ChAdOx1-S/Vaxzevria or Janssen- and 207 receiving mRNA vaccines -Comirnaty/Pfizer-BioNTech or Spikevax/Moderna).

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Coronavirus disease 19 (COVID-19) may present as a multi-organ disease with a hyperinflammatory and prothrombotic response (immunothrombosis) in addition to upper and lower airway involvement. Previous data showed that complement activation plays a role in immunothrombosis mainly in severe forms. The study aimed to investigate whether complement involvement is present in the early phases of the disease and can be predictive of a negative outcome.

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