California Stress, Trauma, and Resilience Study (CalSTARS) protocol: A multiomics-based cross-sectional investigation and randomized controlled trial to elucidate the biology of ACEs and test a precision intervention for reducing stress and enhancing resilience.

Adverse Childhood Experiences (ACEs) are very common and presently implicated in 9 out of 10 leading causes of death in the United States. Despite this fact, our mechanistic understanding of how ACEs impact health is limited. Moreover, interventions for reducing stress presently use a one-size-fits-all approach that involves no treatment tailoring or precision.

A novel antibody treatment reduces deformed wing virus loads in the western honey bee ().

Unlabelled: The deformed wing virus () (DWV) is a key driver of colony loss in the western honey bee (). Here, we demonstrate that orally delivered anti-DWV antibodies can act systemically to reduce DWV loads in naturally infected honey bees. Immunoglobulin Y (IgY) was produced in adult chickens against two DWV proteins, harvested from their eggs, and fed to bees in a sucrose solution.

Interactive effects of genetic liability and combat exposure on risk of alcohol use disorder among US service members.

Background: An improved understanding of pathways to alcohol use disorder (AUD) among service members may inform efforts to reduce the substantial impact of AUD on this population. This study examined whether the relationship between a service-related risk factor (combat exposure) and later AUD varied based on individual differences in genetic liability to AUD.

Methods: The sample consisted of 1203 US Army soldiers of genetically determined European ancestry who provided survey and genomic data in the Army STARRS Pre/Post Deployment Study (PPDS; 2012-2014) and follow-up survey data in wave 1 of the STARRS Longitudinal Study (2016-2018).

Beekeepers Support the Use of RNA Interference (RNAi) to Control .

Current mite management strategies rely heavily on the use of pesticides, adversely affecting honey bee health and leaving toxic residues in hive products. To explore the likelihood of RNAi technology being utilised as an alternative control method for pests like , the opinions of beekeepers on the use of this new biotechnology were obtained using a mixed-methodology approach. In-person surveys and focus groups using the Q method were conducted to discover the willingness of beekeepers to utilise -targeting RNAi treatments in their hives, and to gain feedback to inform decisions before the implementation of this new technology.

RNA interference as a next-generation control method for suppressing Varroa destructor reproduction in honey bee (Apis mellifera) hives.

Background: The Varroa mite (Varroa destructor) is considered to be the greatest threat to apiculture worldwide. RNA interference (RNAi) using double-stranded RNA (dsRNA) as a gene silencing mechanism has emerged as a next-generation strategy for mite control.

Results: We explored the impact of a dsRNA biopesticide, named vadescana, designed to silence the calmodulin gene in Varroa, on mite fitness in mini-hives housed in a laboratory.