Treatment of solid tumors should obligatorily be combined with the in vivo codepletion of tumor-protecting, CD8+/HLA-DR(+)-suppressor T cells by alloreactive donor T cells whose preprogrammed cell death allows a high GvL-effect before GvHD can be established. Results of animal experiments, including more than 6000 mice.

The FACS-analysis of diseases as different as cancer, autoimmune disorders and chronic (retro)viral infections, including HIV-infection, shows -at least temporarily- a common feature of lymphocyte hyperactivation, characterized by cellular activation markers (HLA-DR, CD26, CD38, CD69, CD2R and/or CD30), as well as by solubilized membrane structures, such as beta-2m, sICAM-I, sIL-2R/sCD25, sCD8, and by some oversecreted immunocyte products (e.g. neopterin, lysozyme and/or cathepsin D).

[Novel immunotherapeutic models for neoplastic diseases of the urogenital tract with special attention to bladder carcinoma].

In this review article some novel immunotherapeutic models as well as some new concepts concerning the unspecific and specific T-cell stimulation are discussed briefly. Some of these immunotherapeutic models are restricted to bladder cancer; the others have a generalized meaning. One model, restricted to bladder cancer, is based on the enzymatic++ pretreatment of effector-cells (macrophages, NK-cells), followed by their instillation in the patient's bladder.

Some acid-base balance-dependent urinary parameters and calcium-binding anions in stone formers.

Urinary organic acids were determined by gradual titration of portioned urine samples of moderately and severely recurrent stone patients and compared to those found in healthy controls. An essential deficit of organic acids was found in patients with a high recurrence rate. According to the results, the lack of organic acids in the urine of urolithiasis patients, accompanied by a reduced inhibition of the calcium-oxalate and calcium-phosphate crystallization might be causatively involved in the stone formation.