Publications by authors named "P Lescuyer"
Article Synopsis
- Patients with inflammatory rheumatic diseases (IRD) are at greater risk of severe COVID-19 outcomes, prompting the need to evaluate the effectiveness of mRNA vaccines and treatments in this group.
- A study compared the antibody responses of IRD patients who received two doses of BNT162b2 and mRNA-1273 vaccines, analyzing samples at various intervals after vaccination.
- Results showed that mRNA-1273 led to significantly higher antibody levels compared to BNT162b2, particularly benefiting elderly patients, and specific medications lowered antibody responses.
The identification of clinically relevant biomarkers represents an important challenge in oncology. This problem can be addressed with biomarker discovery and verification studies performed directly in tumor samples using formalin-fixed paraffin-embedded (FFPE) tissues. However, reliably measuring proteins in FFPE samples remains challenging.
View Article and Find Full Text PDFCurrent dose reductions recommended for amoxicillin in patients with impaired kidney function could lead to suboptimal treatments. In a prospective, observational study in hospitalized adults with varying kidney function treated with an IV or oral dose of amoxicillin, amoxicillin concentrations were measured in 1−2 samples on the second day of treatment. Pharmacometric modelling and simulations were performed to evaluate the probability of target attainment (PTA) for 40% of the time above MIC following standard (1000 mg q6h), reduced or increased IV dosing strategies.
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- Letermovir is used for preventing cytomegalovirus (CMV) in patients who have received hematopoietic stem cell transplants (HSCT), and its therapeutic drug monitoring (TDM) was studied for effectiveness and practicality.
- A study involving 40 adult patients found that letermovir levels in the blood remained stable for 70 days after treatment, but there was significant variability among patients.
- The presence of certain medications, such as posaconazole and cyclosporine, increased letermovir levels, while no clear links were found between these levels and the incidence of breakthrough CMV infections.
Therapeutic drug monitoring (TDM) of β-lactam antibiotics is increasingly used to overcome rising antimicrobial resistance and improve antibiotic exposure. However, there is little guidance on target amoxicillin plasma concentrations. We aimed to define these by evaluating associations between amoxicillin concentrations and clinical outcomes.
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