Publications by authors named "P Leber"
Article Synopsis
- The compound 1-exo was synthesized through a Wolff-Kishner reduction process using a cycloadduct formed from 1,3-cyclohexadiene and cyclopropylketene, with minor amounts of its C8 epimer 1-endo present.* -
- The synthesis of the [1,3]-migration product 2-endo was achieved by a selective cyclopropanation reaction of endo-5-vinylbicyclo[2.2.2]oct-2-ene at its exocyclic π-bond.* -
- Gas phase thermal reactions of 1-exo resulted in several transformations, including epimerization to 1-endo, [
Bicyclo[3.2.0]hept-2-enes undergo thermal rearrangement to norbornenes via diradical transition structures.
View Article and Find Full Text PDFAppending a spirocyclopropane linkage to bicyclo[3.2.0]hept-2-ene is achieved by selective kinetic cyclopropanation of 6-methylenebicyclo[3.
View Article and Find Full Text PDFObjective: Methods for characterizing the onset of treatment benefit in major depressive disorder and generalized anxiety disorder have been studied for some time, yet there is no universal agreement as to the best approaches. Our purpose is to summarize the conceptual framework underlying modern methods for characterizing onset and detailed approaches for which there is consensus from the perspective of a clinician, clinical researcher, and statistician. Possible alternatives to unresolved issues are discussed.
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